New version page

UCSD BIBC 102 - Lecture

Documents in this Course
Midterm

Midterm

10 pages

Midterm 1

Midterm 1

10 pages

Lecture

Lecture

9 pages

Lecture

Lecture

47 pages

Nitrogen

Nitrogen

17 pages

Lecture

Lecture

33 pages

Lecture 9

Lecture 9

24 pages

Lecture

Lecture

6 pages

Lecture

Lecture

39 pages

Lecture

Lecture

3 pages

Glycogen

Glycogen

14 pages

Lecture

Lecture

15 pages

Lecture 3

Lecture 3

28 pages

Lecture

Lecture

2 pages

Lecture

Lecture

5 pages

FINAL KEY

FINAL KEY

17 pages

Lecture 4

Lecture 4

44 pages

Lecture

Lecture

5 pages

Lecture 2

Lecture 2

45 pages

Midterm

Midterm

11 pages

Midterm

Midterm

11 pages

Load more
Upgrade to remove ads

This preview shows page 1-2-20-21 out of 21 pages.

Save
View Full Document
Premium Document
Do you want full access? Go Premium and unlock all 21 pages.
Access to all documents
Download any document
Ad free experience
Premium Document
Do you want full access? Go Premium and unlock all 21 pages.
Access to all documents
Download any document
Ad free experience
Premium Document
Do you want full access? Go Premium and unlock all 21 pages.
Access to all documents
Download any document
Ad free experience
Premium Document
Do you want full access? Go Premium and unlock all 21 pages.
Access to all documents
Download any document
Ad free experience

Upgrade to remove ads
Unformatted text preview:

Cutaway diagram of a mitochondrion.Mitochondria. (a) An electron micrograph ofan animalmicrograph ofan animal mitochondrion.Voet, Fundamentals, 3rdFig. 18.2 and 3Functional compartmentalization of mitochondrionImpermeable for ionsRespoiratory chainInner membraneOuter membrane pyPermeable, VDACCi i id lMatrix Citric acid cycleFatty acid oxidationCompare to bacteriumOxidative phosphorylation couples electron with proton transportCli fltt t()tCoupling of electron transport (green arrow) to proton pumping (blue arrows). The resulting proton gradient is used for ATP synthesis.Voet, Fundamentals, 3rdFig. 18.20The role electrochemical energy in cellsThe mitochondrial electron-transport chain iNADH i tfd ttilusing NADH as an input of redox potentialVoet, Fundamentals, 3rdFig. 18.8The mitochondrial electron-transport chain.Voet, Fundamentals, 3rdFig. 18.7Voet, Fundamentals, 3rdOxidation states of the coenzymes of complex I. coe y es o co p e(a) FMN (left)(b) CoQ (right)Transfer reducing equivalents (H•)Voet, Fundamentals, 2nd Fig. 18.11Structures of the common iron–sulfur clusters. [2Fe2S] cluster and [4Fe4S] cluster[2Fe–2S] cluster and [4Fe–4S] cluster. Voet, Fundamentals, 3rdTransfer of electronsPage 605Structure of electron flow through complex IFigure 18-11Voet, Fundamentals, 3rdComplex IpElectron Microscopy structure of bovine mitochondrial NADH dehydrogenaseMatrixInner membraneIntermembrane spaceInter-membrane spaceComplex IIE.coli succinate dehydrogenase(PDB accession 1NEK)OAA = oxaloacetate (inhibitor) CL di li i iVoet, Fundamentals, 3rdCL = cardiolipin is a membrane phospholipidFig. 18.13Complex IIIYeast cytochrome bc1(PDB accession 1KYO)Voet, Fundamentals, 2ndPorphyrin rings in cytochromes. Voet, Fundamentals, 3rdTransfer electronsBox 18.1cTh Q lThe Q cycle Q-cycle of complex III is a Qcyc e o co p e s aproton pump mechanismVoet, Fundamentals, 3rdFig. 18.15Q-cycle of complex III showing coupling of e-/H+ transport Per double-cycle 3 ubiquinones are involved, two reduced and one oxidized formPer double-cycle 3 ubiquinones are involved, two reduced and one oxidized form2 quinones QPand QN3rdquinone, QPon enzymeFig19-11, Cox, LehningerComplex IV Bovine heart mitochondrial cytochrome C oxidase (dimer shown) (PDB accession 1OCC)Voet, Fundamentals, 3rdFig. 18.17Complex IV (cytochrome C oxidase) structure and mechanismFig19-12, Cox, LehningerFig. 18.18; Voet, Fundamentals, 3rdLow (3.9 Å) resolution electron densityelectron density map of the yeast mitochondrial F1–c10 complex. (a) A view from withinA view from within the inner mitochondrial membrane with the matrix abovethe matrix above. (right) Model of the E. coli F1F0–ATPase.Fig. 18.23 to 25 Voet, Fundamentals, 3rdBox 18-4 figure 2Voet, Fundamentals, 3rdRegulation of Krebs cycle by energy chargeby energy chargeFigure 18-29 part 1Voet, Fundamentals,


View Full Document
Download Lecture
Our administrator received your request to download this document. We will send you the file to your email shortly.
Loading Unlocking...
Login

Join to view Lecture and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view Lecture 2 2 and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?