Chiral Olefin LigandsNew Spectators in Asymmetric CatalysisGlorius, F. Angew. Chem. Int. Ed. 2004, 43, 3364-3366Fischer, C.; Suzuki, T.; Carreira, E. M. J. Am. Chem. Soc. 2004, 126, 1628Literature PresentationHu, GangMichigan State UniversityJune 24, 2004Dr. Frank GloriusMax-Planck-Institut für KohlenforschungKaiser-Wilhelm-Platz 1D-45470 Mülheim an der RuhrGermanyTel.: +49 208 306-2428E-mail: [email protected] and Research Experiencesince 08/2001Habilitation (assist. prof.) at the Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr and theUniversity of Dortmund2000 – 2001 Postdoctoral studies with Prof. D. A. Evans, Harvard University1997 – 2000 PhD thesis with Prof. A. Pfaltz, University of Basel and Max-Planck-Institut für Kohlenforschung,Mülheim/Ruhr1996 – 1997 Diploma thesis with Prof. A. Pfaltz and Prof. H. M. R. HoffmannMax-Planck-Institut für Kohlenforschung, Mülheim/Ruhr and the University of Hannover1995 – 1996 Research with Prof. P. A. Wender, Stanford University1992 – 1997 Studies of chemistry at the University of Hannover1991 – 1992 Military service.Erick M. CarreiraProfessor of Organic ChemistryProf. Dr. Erick M. CarreiraLaboratorium für Organische ChemieETH Hönggerberg8093 Zürich, SwitzerlandTel : +41-1-632 2830Fax: +41-1-632 1328e-mail : [email protected] and Research Experience1984, B.S. UIUC, Scott E. Denmark1990, PhD. Harvard, David A. Evans1992, Postdoc fellow, CIT, Peter Dervan1992-1997, CIT, 1996, associate professor, 1997, full professor1998-, ETH Zurich, full professorOlefin as ligand in transition metal complexZeise’s salt: K[PtCl3(C2H4)]The role of olefin ligand in a reaction:(1) Dissociate from the metal orundergo chemical conversion(2) SpectatorYin, J.; Rainka, M. P.; Zhang, X-X.; Buchwald, S. J. Am. Chem. Soc. 2002, 124, 1162Lloyd-Jones, G. C.; Kocovsky, P. et al. Chem. Eur. J. 2000, 6, 4348[2.2.1] diene ligand in asymmetric catalysisHayashi, T.; Ueyama, K.; Tokunaga, N.;. Yoshida, K. et al. J. Am. Chem. Soc. 2003, 125, 11508Model to rationalize the stereochemical outcomeFischer, C.; Defieber, C.; Suzuki, T.; Carreira, E. M. J. Am. Chem. Soc. 2004, 126, 1628[2.2.2] diene ligand in asymmetric catalysisNot working inNot working inthis reactionthis reactionConclusions:1. As a consequence of chelation, dienes with the propergeometry can form intriguingly complex which may result incatalyst with enhanced stability, selectivity and catalyticactivity.2. Bidentate ligands consisting of an alkene unit and anothercoordination element, as indicated by Rh and Ir complexesshould become a valuable class of ligands with new