Honors Collegium 70A (UCLA) and Science & Society 70A (UC Davis) Genetic Engineering In Medicine, Agriculture, & Law Professors Bob Goldberg & John Harada Winter 2010 LECTURES & GUEST SPEAKER DISCUSSIONS: Tuesday & Thursday 3:30-6:00 → La Kretz 120 DISCUSSION SECTIONS: Wednesdays → La Kretz 100: 12-2, 2-4 & 4-6 REQUIRED TEXTS: Introduction to Biotechnology, 2nd Edition (W. J. Thieman & M. A. Palladino) The Double Helix (J. D. Watson) Scientific American & Other Articles (Downloaded from the Blackboard HC70A website or the Goldberg HC70A website using Adobe Reader 6.0 or later) OFFICE HOURS: Friday: Noon-2:00PM → Life Sciences 2832 Phone: 310-825-9093; Email: [email protected] GOLDBERG HC70A WEBSITE: http://www.mcdb.ucla.edu/Research/Goldberg/HC70A_W10/ HC70A BLACKBOARD WEBSITE: http://www.lsic.ucla.edu/classes/winter10/ BRUINCAST: http://www.oid.ucla.edu/webcasts/courses/2009-2010/2010winter/hc70a-1/ ADMINISTRATIVE ASSISTANT: Jennifer Gottesfeld ([email protected]) (310-825-3270) Office Hours: Monday-Friday 1-6PM → LS 2835 TEACHING FELLOWS: 12-2 – Daisy Robinton ([email protected]) Office Hours: Tuesday 11AM-1PM → LS2805 2-4 – Jordan Fischer ([email protected]) Office Hours: Thursday 1-3PM → LS2805 4-6 – Kristin Gill ([email protected]) Office Hours: Monday 1-3PM → LS2805 LECTURES: Lectures will be webcasted and audio podcasted. They can be viewed from the UCLA BruinCast site using RealPlayer. GUEST LECTURES: Guest speakers have been invited to highlight the real-life impacts of genetic engineering and new scientific breakthroughs on society. Note: Attendance is required. DISCUSSION SECTION: Discussion Section will be taught as an Undergraduate Seminar in Socratic style and will focus on scientific articles and debates that relate to the history of genetic engineering and its current applications. Articles will introduce important concepts and teach you how to read and think about science. Focus your reading around four questions: (1) What is the question being addressed by the article? (2) What are the technologies/approaches being discussed? (3) What is the significance of the technology and how does it apply to real-life situations? (4) What ethical issues arise, if any, as a consequence of the new technology? Note: You must read the articles and text background material before discussion section and come prepared to participate in a thoughtful and interactive manner. QUIZZES: A Take-Home Quiz will be handed out at the end of each Discussion Section and will also be posted on the class website. The take-home quiz focuses on the articles/topics/concepts covered in each Discussion. Quizzes will count 25,000 points each. Note: You may work together in groups in order to solve the quiz problems. However, each of you must learn how to solve the quiz problem and hand in your own quiz. A Discussion participation grade of up to 50,000 points will be assigned at the end of the quarter. Quizzes are due at the beginning of the next Discussion Section.CLASS RECEPTIONS & DINNERS: There will be a catered all-class reception for each guest speaker immediately following their Thursday lecture. This will give you an opportunity to interact with the speakers who are experts in their chosen fields. In addition, I will take groups of students to dinner throughout the quarter following the reception. The dinners will begin the first week in February, may also include the guest speakers, and will be a unique experience! Check the dinner group list that will be handed out in class for the week and day that you are scheduled to attend dinner. DOUBLE HELIX REPORT: You will write a short report on The Double Helix by J. D. Watson that will count 50,000 points. Guidelines will be handed out in class. The Double Helix Report is due at the beginning of class on Tuesday, January 19 (Week 3) EXAMS: Exams include a Take-Home Exam and two All-Class Oral Exams. Take-Home Exam questions will be handed out in class during Week 4 and will count 400,000 points. The mid-term oral exam will cover questions on the Take-Home Exam and will count 100,000 points. Final Oral Exam questions will be handed out in class during Week 9 and will count 175,000 points. The Exam Schedule is: Take-Home Exam: Due Thursday, February 11 at the beginning of class (Week 6) All-Class Mid-Term Oral Exam: Thursday, February 11, La Kretz 120 (Week 6) All-Class Final Oral Exam: Thursday, March 11, La Kretz 120 (Week 10) GRADING: You will be able to earn ONE MILLION regular points and a number of BONUS POINTS during the quarter. Your grade for this quarter will be based on 1,000,000 points, although you have the potential for earning more than 1,000,000 points. Regular points will be divided as follows: Total Points % Grade Double Helix Report 50,000 5 Discussion Quizzes 200,000 20 Discussion Participation 50,000 5 Take-Home Exam 400,000 40 Mid-Term Oral Exam 125,000 12.5 Final Oral Exam 175,000 17.5 TOTAL 1,000,000 100 The following guidelines will be used to assign grades: A (>90%), B (80-89%), C (70-79%), D (60-69%), F (<60%). Your grade will be assigned using the following formula: % Total Points = [(Regular points + Bonus points)] X [100] [(1,000,000)]DATE TOPIC 1/5 Lecture 1: The Age of DNA: What is Genetic Engineering? Demonstrations: Isolating DNA & Classical Genetic Engineering 1/7 Film: Race for the Double Helix DISCUSSION 1: The Manipulation of Genes Potential Biohazards of Recombinant DNA Molecules Recombinant DNA Debate 1/12 Lecture 2: What Are Genes & How Do They Work: Part One Demonstrations: Gel Electrophoresis & Bacteria "Cloning" DOUBLE HELIX REPORT QUESTIONS HANDED OUT BACTERIA “CLONING” GUIDELINES HANDED OUT 1/14 Speaker: Dr. Robert Wayne, PhD: Hunting For Dog Ancestors All-Class Reception DISCUSSION 2: Useful Proteins from Recombinant DNA Discovering Genes for New Medicines -------------------------------------------------------------------------------------------------------------------------------------------- 1/19 Lecture 3: What Are Genes & How Do They Work: Part Two Film: Kerry Mullis and PCR DOUBLE HELIX REPORT DUE 1/21 Speaker: Richard Hamilton, PhD: Engineering Plants For Biofuels All-Class Reception DISCUSSION 3: