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L14: 14 Lectures past and 11 to goPart I: ‘The cell as a well-stirred bioreactor’1topics- Lambda phage lysis-lysogeny switch- Synthetic genetic switch- Switches as memory storage- Chemotaxis: perfect adaptation or not?- Synthetic genetic oscillatorsmain assumption- well-stirred reactor- absence of chemical gradients(justification: small cells, diffusion mixes)Switch fromSystems MicrobiologytoSystems Cell BiologyThe importance of diffusion and gradientsfor cellular regulation2Part II: Systems Cell Biology‘Importance of gradients and diffusionin cellular regulation’3After two lectures on diffusion and reaction-diffusion equations,we will focus during the coming lectures on the followingbiological systems:1. Eukaryotic chemotaxisGradient sensing in Dictyostelium(aka‘amoeba’)2. Computing the middle of a cellPole-to-pole oscillations in Escherichia coli3. Self organization of the


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MIT 8 591J - Lecture Notes

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