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WSU BIOLOGY 107 - Bulk Transport and Plasma Membrane

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BOLOGY 107 Lecture 9Outline of Last Lecture I. Organellesa. Mitochondriab. Chloroplast c. Endosymbiosis theoryd. Peroxisome e. CytoskeletonOutline of Current Lecture II. Organellesa. Bulk Transportb. Plasma MembraneCurrent LectureOrganelles1) Bulk Transport a) Exocytosis i) Secretion of materials(1) Vesicles from endomembrane system fuses with plasma membrane, releasing the contents outside the cell2) Plasma Membranea) Segregate domainsi) Keep outside on the outside and the inside inb) Semi-permeable membranei) Allows certain molecules to pass, blocks othersc) Basis for organizationi) Micro-fibrils anchor to membraned) Information relay via signalse) Contains phospholipid bilayer as main structure scattering of cholesterol, proteins, and associated carbohydratesf) Visualizing structurei) Fluid mosaic model(1) Mosaic o lipids and macromolecules(2) Random distribution(3) Free motility of moleculesThese notes represent a detailed interpretation of the professor’s lecture. GradeBuddy is best used as a supplement to your own notes, not as a substitute.(4) Some subdomains, like lipid rafts, are not random or freely mobileg) Membrane fluidity and proteinsi) Fluidity (1) Dynamic, constant lateral movement, rarely flipping movement(2) Antigens, or antibody targets, show fluidity(a) When rat and human cells with different antibodies fused, antibodies of both cells were found in almost even distribution around the cell rather than split in half(3) Affected by temperature, if the phospholipids are saturated or unsaturated, cholesterol, and integral proteinsh) Proteins i) Integral (1) Directly imbedded in membrane (transmembrane)(2) Some only go through half the membrane, not through both sides(3) Made in the endomembrane systemii) Peripheral (1) Loosely attached(2) Associated with phospholipids or integral proteinsiii) Function (1) Transport, enzymatic activity, signal transduction, cell recognition, intercellular joining, cytoskeletal attachment(2) Target for viruses(a) Infect cells by specific binding to cell-surface proteins (b) Immunological, pharmacological, or genetic intervention prevents


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WSU BIOLOGY 107 - Bulk Transport and Plasma Membrane

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