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Economics 560P. ConwayCIPLA Ltd. And the Provision of Anti-AIDS PharmaceuticalsCIPLA, Ltd.HIV TreatmentsEconomics 560 P. Conway CIPLA Ltd. And the Provision of Anti-AIDS Pharmaceuticals It’s 2001, and G. G. Brereton is a busy man. He heads the Global Intellectual Property Office at GlaxoSmithKline (GSK), a multinational pharmaceutical corporation with operations throughout the world. He is tasked with defending GSK’s patents against foreign imitators. In recent months he has been occupied with infringements against GSK patents for antiretroviral drugs – the pharmaceuticals used to treat the symptoms of HIV and AIDS. This week has been especially hectic: CIPLA Ltd. of India has just announced its offer to supply an antiretroviral “cocktail” to Sub-Saharan African countries for 3 percent of the price that GSK charges for its anti-AIDS cocktail. Top management at GSK wants options for responding to this surprising offer. G. G. has been given the job of (1) coming up with potential responses by GSK to this initiative and (2) identifying that option that best assures the continued profitability of the firm now and into the foreseeable future. He has till Friday to do it! HIV/AIDS. One of the most vexing public-health problems of the new century has been the explosion in cases of human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome (AIDS). In the year 2000, the United Nation AIDS Organization (UNAIDS) reported that 36.1 million people worldwide were living with HIV or AIDS. There were 5.3 million new cases of HIV infection in the year, and 3.0 million deaths attributable to HIV infection. Since its first diagnosis, the AIDS epidemic has claimed 21.8 million lives. This epidemic has been centered, and has had the greatest impact, in Africa. 25.3 million of those suffering from HIV and AIDS are in Africa The 1990s were years of pharmaceutical breakthrough in the prevention of HIV infection and the treatment of AIDS. Five large multinational pharmaceutical corporations (Merck, Bristol-Myers Squibb, Boehringer Ingelheim, GlaxoSmithKline, and Roche) developed a series of drugs found to be effective in treating AIDS. Each drug was somewhat effective on its own, but physicians soon found that the drugs were most effective if used in combination in a drug “cocktail”. The cost per patient per year of this “cocktail” treatment in the US and western Europe was $10,000 to $12,000 USD. This was a very expensive recurrent treatment for patients in developed countries, and was clearly not affordable on a widespread basis in Africa, where in some countries per capita incomes are only one percent of the cost of the “cocktail”.CIPLA, Ltd. CIPLA Ltd is a pharmaceutical company based in India. It is large by Indian standards, with the equivalent of $177 million USD in revenues in the year 2000. Its ratio of after-tax profit to revenue of nearly 17 percent indicates that it has been quite profitable. The company manufactures 400 medications for sale in the Indian and foreign markets, and in recent years has exported its products to 125 countries. It is known on world markets as a specialist in generic pharmaceuticals. The Chemical, Industrial and Pharmaceutical Laboratories (CIPLA) Ltd was formed in 1935 in Mumbai, India by Dr. Khwaja Abdul Hamied. Dr. Hamied studied chemistry in Berlin in the 1920s and then returned to India to begin CIPLA in a rented bungalow in 1935. With the beginning of the Second World War, the supply of pharmaceuticals from Western sources was disrupted; CIPLA stepped into the breach to provide generic equivalents of those pharmaceuticals. The corporation reported its last operating loss in 1939, and has been consistently profitable since that time. CIPLA Ltd. Millions of rupees 2000 1999 1998 1997 1996 Total Assets 5950 4960 3829 2964 3127 Buildings 1617 1449 1225 1067 944 Capital 1950 1404 728 305 32 Current Assets 2383 2107 1876 1592 2151 Net Worth 5755 4624 3643 2747 2119 Total Liabilities 196 336 186 217 1008 2000 1999 1998 1997 1996 Revenues 7955 6451 5410 4779 3662 Expenditures 6229 4906 4060 3752 3287 B.T. profit 1726 1545 1350 1027 375 A.T. profit 1330 1150 1020 707 290 Dividends 197 166 121 77 24 Retained Earnings 1133 983 899 630 265 Rupees per USD 45 43 42 36 35 His son Yusuf—who obtained a Ph.D. in Chemistry from Cambridge University— joined the corporation in 1960 as the director of research and development. In 1972, with the death of K.A. Hamied, Yusuf became the chief executive officer of the corporation. Its major marketis India, but it has also been successful selling its product in foreign countries. In 1985 the US Food and Drug Administration gave its seal of approval to CIPLA’s bulk drug manufacturing facilities. Cipla, Ltd is currently the third largest pharmaceutical manufacturer in India, with plants throughout the subcontinent. A map indicating the location of these plants is provided at the end of this case. CIPLA ignited a firestorm in international pharmaceutical circles in February 2001 with its offer to sell an anti-AIDS “cocktail” to African countries for a small fraction of the price charged by Western drug manufacturers. It has offered to supply the medical group Doctors without Borders with its three-drug cocktail for $350 USD per patient per year, and will make the same treatment available to government agencies in those countries for $600 USD per patient per year. Other generic drug companies in India have since duplicated CIPLA’s offer at even lower price per patient. HIV Treatments A pharmaceutical breakthrough occurred in the mid-1980s in the search for medicines to treat AIDS. Investigators discovered that the causal organisms of the various conditions now lumped together in the diagnosis HIV shared the common classification of retroviruses. Drugs that reduce the “load” of these retroviruses in the patient, and thus suppress the symptoms of AIDS, are referred to as antiretroviral therapies. Since retroviruses mutate rapidly to counteract the effect of any one medicine, the most potent treatments currently available involve combinations of drugs. Zidovudine (or AZT), the first antiretroviral medicine proposed for AIDS treatments, was introduced by Glaxo (now GlaxoSmithKline) in the mid-1980s. This demonstrated initial positive effects, but its effectiveness


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