John DiGregorio, M.D., Ph.D. ADRENERGIC BLOCKING DRUGS I Reading: Rang & Dale’s Pharmacology, 6th Edition, 2007, Chapter 11 Objectives: 1. Define the differences between a selective and non-selective adrenergic blocking drugs 2. Difference between alpha and beta blocking drugs 3. Name the most useful alpha blocking drugs 4. What are the therapeutic advantages of selective and non-selective blocking drugs? 5. What are the classifications of the adrenergic blocking drugs? DRUGS Phentolamine (NS)* Reserpine Phenoxybenzamine(NS) Guanethidine Prazosin (S) Guanadrel Doxazosin (S) Metyrosine Tamulosin (S) I. Definitions II. Alpha-Adrenergic Blocking Drugs: Selective(S) vs. Nonselective(NS)* A. Mechanism of Action B. Pharmacokinetics C. Effects on Organ Systems D. Therapeutic Uses E. Adverse ReactionsIII. Adrenergic Neuronal Blocking Drugs A. Mechanism of Action B. Pharmacokinetics C. Effects on Organ Systems D. Therapeutic Uses E. Adverse
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