GSU BIOL 6576 - Exam 1 Study Guide (8 pages)

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Exam 1 Study Guide

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Exam 1 Study Guide


a review of the first 4 lectures of the class. general virology, general neurobiology, CSF, and pathology.

Study Guide
Georgia State University
Biol 6576 - Neurovirology
Neurovirology Documents

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BIOL 4576 Exam 1 Study Guide Lectures 1 3 Lecture 1 January 15th Virus an intracellular parasite that must use the host cell s machinery to make new progeny infectious viral particles A virus cannot grow metabolize or synthesize proteins on its own They must be viewed through an electron microscope except pox viruses that can be seen by light microscopes Definitions virion infectious viral particle there can be non infectious particles capsid protein coat capsomere morphological subunit of a capsid nucleocapsid capsid containing genetic material envelope lipoprotein membrane that surrounding the nucleocapsid tegument area between envelope and nucleocapsid usually containing proteins and enzymes Capsids can be icosahedral helical or complex Icosahedral capsids have a 5 3 2 symmetry Helical capsids are shaped like a spiral and have RNA as their genome Complex viruses are shaped like bricks They also have lateral bodies and a core They can replicate in viral factories in the cytoplasm of a cell These complex viruses are pox viruses Any of these types of viruses can have an envelope The virus acquires its envelope from any membrane of the cell including the golgi ER nuclear membrane or the plasma membrane This is called budding These enveloped can either be tight or loose fitting Loose envelopes are pleomorphic because their shape can change Viral proteins are inserted into the envelope They assist in attachment and immune response These structures are known as peplomers or spikes If a virus is enveloped it cannot be infectious without one They are also less stable that a naked virus because the envelope is more sensitive to environmental pressures like heat and ion concentration The tegument can function as an antigen with regards to an immune response They are also the first proteins to take action when the virus enters the cell Genomes viruses can have DNA or RNA be linear or circular be single stranded or double stranded all in one piece or segmented DNA viruses

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