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UNIT CELL PROCESSESBone RemodelingMassachusetts Institute of TechnologyHarvard Medical SchoolBrigham and Women’s HospitalVA Boston Healthcare SystemBone (Trabecular) StructureOsteoporotic:PostmenopausalNormalEffects (bone resorption) of the alteration in chemical regulator (lack of estrogen).Two photos removed due to copyright restrictions. Postmenopausal bone is much less dense.Slope = ~20.11101000.01 0.10 1.00Apparent density (g/cc)Ultimate strength (MPa)Figure by MIT OpenCourseWare. Data from AAOS Orthop. Basic Sci., 2000.UNIT CELL PROCESSESFIBROUS TISSUE REMODELINGFibroblast + ECM Sol. ECM + Reg.Fibroblast + ECM New ECM + Reg.Reg.Synthesis:collagenaseSynthesis:collagenUNIT CELL PROCESSESBONE REMODELINGOsteoclast + ECM Sol. ECM + Reg.Osteoblast + ECM New ECM + Reg.DegradationFormationSynthesis:collagenase, H+Synthesis:collagenUNIT CELL PROCESSESBONE REMODELINGOsteoclast + ECM Sol. ECM + Reg.Osteoblast + ECM New ECM + Reg.Reg.Synthesis:collagenase, H+Synthesis:collagenUNIT CELL PROCESSESBONE REMODELINGOsteoclast + ECM Sol. ECM + Reg.Osteoblast + ECM New ECM + Reg.Reg.Synthesis:collagenase, H+Synthesis:collagenUNIT CELL PROCESSESBONE REMODELINGOsteoclast + ECM Sol. ECM + Reg.Osteoblast + ECM New ECM + Reg.Reg.Synthesis:collagenase, H+Synthesis:collagenUNIT CELL PROCESSESBONE REMODELINGOsteoclast + ECM Sol. ECM + Reg.Osteoblast + ECM New ECM + Reg.IL-1, PGE2PGE2TGF-bSynthesis:collagenase, H+Synthesis:collagenUNIT CELL PROCESSESBONE REMODELINGOsteoclast + ECM More OCs + Reg.Precursor CellsMigrationOsteoblast + ECM New ECM + Reg.IL-6Synthesis:collagenCSF-GMNo EffectUNIT CELL PROCESSESBONE REMODELINGOsteoclast + ECM Sol. ECM + Reg.Osteoblast + ECM New ECM + Reg.Reg.Synthesis:collagenase, H+Synthesis:collagenMFMFMIT OpenCourseWarehttp://ocw.mit.edu 20.441J / 2.79J / 3.96J / HST.522J Biomaterials-Tissue InteractionsFall 2009 For information about citing these materials or our Terms of Use, visit:


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