Forensic Biology by Richard LiBasicsSlide 3Slide 4Statistical AnalysisChapter 23: Evaluation of the Strength of Forensic DNA Profiling ResultsMendelian GeneticsMendel’s First Principle- segregation of allelesMendel’s Second Principle- independent assortmentMeiosis- gametes formed▪46 23 Diploid: 22 pairs of autosomes and 2 sex chromosomes (XX & XY)Forensic Biology by Richard Li 2Inheritance of genes measured using probabilitiesPopulation Genetics: Studies the causes of the observed patterns of genetic variationAllele FrequencyGenotype FrequencyForensic Biology by Richard Li 3Hardy-Weinberg Principle1900’sAllows predictions of the genotype frequencies to be made from the allelic frequenciesConditions: ▪Population is large▪Randomly mating▪Absent from mutation, migration, and natural selectionForensic Biology by Richard Li 4Evaluate the strength of the matchTwo approaches:Profile ProbabilityLikelihood Ratio Forensic Biology by Richard Li
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