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UCSD BIBC 102 - Lecture

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Glycolysis GluconeogenesisF6PF2 6bPF1,6bPPhosphofructo kinase Fructose 1,6 bi-phosphataseCitrate F2,6bPAMPF2,6bPAMPATPCitrate PEPPEP carboxy kinaseADPH+PEPPyruvatePEP carboxy kinaseOxaloacetate F1,6bPATPPyruvatekinase yPyruvate carboxylaseAcetyl-CoAADP AlanineTable 23-1 Regulators of Gluconeogenic Enzyme Activity.Voet & Voet, Biochemistry, 3rded,Substrate cyclingResting muscle Active muscleVoet, Fundamentals, 3rdgBoth enzymes active Phosphatase incactiveFig. 15.25The Cori cycle1 Glucose 2 Lactate + 2 ATP (anaerobic glycolysis in muscle)2 Lactate + 6 ATP1 Glucose (gluconeogenesis in liver)2 Lactate + 6 ATP 1 Glucose (gluconeogenesis in liver)Voet, Fundamentals, 3rdFig. 22.6Glucose alanine cycleVoet, Fundamentals, 3rdFig. 22.7Cell type specific substrate-specificity of lactase dehydrogenase favors glycolysis in skeletal muscle (M4) and pyruvate formation in heart (H4).g yco ys s s e eta usc e ( ) a d py u ate o at o ea t ( )M.C. McMurray, Essentials of human metabolism, 2nded., 1983,


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UCSD BIBC 102 - Lecture

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