Tuesday, Thursday 11-12.15 Coker 201BIOL 252 Bloom and Shemer Fall 2010, pg. 1BIOL 202 (section 007) Molecular Biology and Genetics Fall 2010Tuesday, Thursday 11-12.15 Coker 201This course emphasizes the learning of the basic principles of molecular biology and genetics. We willcover more than 150 years of discoveries, starting with Mendel’s instrumental set of genetic crossesand ending up with microarrays and how they help us in cancer therapy. One of our main goals in thiscourse is to teach you how to “think Genetics” and develop your critical, scientific thinking. Thus, we willlearn about genetic and molecular mechanisms by revealing them via the actual experiments that led tothe discovery of these mechanisms. During recitations, teaching assistants will help you to understand material that was covered in lectures,as well as go over homework exercises that will give you a better understanding of the quantitative aspects of genetics. BIOL 202 requires a substantial amount of individual effort. Be active throughout the semester and make sure you take advantage of every possible resource that will help you to successfully complete this course.Your instructors Prof. Kerry Bloom Fordham Hall 623Office hours: Tues. Thurs 1 to 3:30 , W 1-2 or by appointment Web page: http://www.bio.unc.edu/Faculty/Bloom/ Email : [email protected]. Gidi Shemer Wilson Hall G41Office hours: M,W 2:00 to 5:00 or by appointment Web page: http://www.bio.unc.edu/Faculty/Shemer/ Email: [email protected]:Amanda Hicks (Office hrs.: Tues 2-4, 418 Fordham) 701 W 1:00-1:50; 702 W 2:00-2:50 [email protected] 705 Th 1:00-1:50 706 Th 2:00-2:50 Miranda Welsh (Office hrs.: Tues 1-2, 404 Coker) 703 W 3:00-3:50; 704 W 4:00-4:[email protected] 707 Th 3:00-3:50; 708 Th 4:00-4:50 TEXTBOOK: GENETICS: From genes to genomes, 3rd Ed. Hartwell et al (2008) COURSE WEBSITE: http://blackboard.unc.eduFor general announcements and assignments, visit the Bb site Class Slides will be posted on Bb.BIOL 252 Bloom and Shemer Fall 2010, pg. 2SCHEDULE1. Aug 24 Introduction: Genes, Genomes and Genetic Analysis (KB)- Ch12. Aug 26 DNA: the Molecule of Heredity (KB) Ch6 (6.1-6.3)3. Aug 31 How traits are transmitted: Mendelian Inheritance (KB) Ch 24. Sep 02 How traits are transmitted: Extensions to Mendel (KB) Ch35. Sep 07 The chromosome theory of Inheritance (KB) Ch 46. Sep 09 Genetic Linkage and Chromosome Mapping I (KB) Ch 57. Sep 14 Genetic Linkage and Chromosome Mapping II (KB) Ch 58. Sep 16 Molecular Biology of DNA Replication I (KB) Ch 6 Sep 21 Exam 1 (Covers lectures # 1-7 inclusive) 9. Sep 23 Molecular Biology of DNA Replication II and Recombination (KB) Ch 610. Sep 28 Molecular Mechanisms of Mutation and DNA Repair (KB) Ch711. Sep 30 Molecular Organization of Chromosomes (KB) Ch1312. Oct 05 Human Karyotypes and Chromosomal Behavior (KB) Ch 1413. Oct 07 Human Genetics (KB)Oct 12 University day Oct 14 Exam 2 (Covers lectures # 8-13 inclusive)14. Oct 19 How Genes Travel- Bacterial Genetics I (GS) Ch15 Oct 21 Fall Break 15. Oct 26 Bacterial Genetics II: The Bead Theory is falling apart (GS) Ch 15 and 7.216. Oct 28 Gene Expression: the flow of genetic information (GS) Ch 817. Nov 02 Gene Expression- Transcription (GS) Ch 818. Nov 04 Gene Expression- Translation (GS) Ch 819. Nov 09 Gene Regulation in Prokaryotes (GS) Ch 1720. Nov 11 Gene Regulation in Eukaryotes (GS) Ch18Nov 16 Exam 3 (Covers lectures # 13-19 inclusive) (GS) 21. Nov 18 Gene Regulation III: more RNAs than you ever imagined (GS) Ch18 22. Nov 23 DNA recombinant technology: entering a new era (GS) Ch 9Nov 25 Thanksgiving23. Nov 30 DNA recombinant technology: A PHD in 75 minutes (GS) Ch 924. Dec 02 Developmental Genetics: why don’t we have duck feet? (GS) 25. Dec 06 Molecular Genetics of Cancer (GS) Ch19 26. Dec 08 Molecular Genetics of Cancer – fight and hope (GS) Ch19 and 10.3Dec 12 Final Exam (semi-cumulativee, including lectures # 20-26 inclusive)BIOL 252 Bloom and Shemer Fall 2010, pg. 3ATTENDANCE: Students are expected to attend and participate in lectures and recitations. While the course follows the textbook, some of the material discussed in lecture may not be found in the text. Youare responsible for all material and announcements made in lectures and recitations. You are not responsible for textbook material that was not covered in class, unless it was specifically assigned. Homework and assigned readings will be posted on Blackboard under “assignments”.GRADING95% of your grade will be based on your exams and 5% on recitations and discussions. There are threemidterm exams and one final. The final will be a semi-cumulative exam: half of the exam will cover the material taught in the last quarter of the course and half will be cumulative. All the exams are graded equally. Grades will not be assigned for individual exams, only points; you will be able to see how you did from a posted distribution of scores after each test. Final grades will be assigned on a curve based on the total number of points for the entire semester. In case the class average will be higher than the standard 75, we will use standardized grading (A: 93-100; A-: 90-92; B+: 87-89; B: 83-86; B-: 80-82; C+: 77-79; C: 73-76; C-: 70-72; D+: 66-69; D: 60-65; F <60)Exams must be taken on the dates indicated during the regular class period; no makeup exams except in special circumstances, i.e., medical or family emergency documented in writing. The makeup test may be an oral exam.POLLEVERYWHEREIn this class you will use a polling system to answer questions that I pose during class. You can submit your responses using a mobile phone, laptop or other mobile device with a WiFi connection, such as an iPod Touch or an iPad. Before you can participate, you'll need to create an account. Please feel free to email Dr. Gidi Shemer if you have any questions or concerns.Click the link below to go to the course's Poll Everywhere registration page. http://www.polleverywhere.com/participants/new?p=1qk9-96sa1.If you already have a Poll Everywhere account, click the log in link, log in and click Grant Access. If you are already successfully registered with the account that UNC instructors are sharing, you’ll receive a message that you are already registered with Suzanne Cadwell’s account. 2. Enter your name, UNC-CH Onyen email address, and a password. This