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Berkeley INTEGBI 200A - The Hennig Principle: Homology, Synapomorphy, Rooting issues

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Integrative Biology 200A "PRINCIPLES OF PHYLOGENETICS" Spring 2008 University of California, Berkeley B.D. Mishler Jan. 29, 2008. The Hennig Principle: Homology, Synapomorphy, Rooting issues The fundamental idea that has driven recent advances in phylogenetics is known as the Hennig Principle, and is as elegant and fundamental in its way as was Darwin's principle of natural selection. It is indeed simple, yet profound in its implications. It is based on the idea of homology, one of the most important concepts in systematics, but also one of the most controversial. What does it mean to say that two organisms share the same characteristic? The modern concept is based on evidence for historical continuity of information; homology would then be defined as a feature shared by two organisms because of descent from a common ancestor that had that feature. 1. The Hennig Principle Hennig's seminal contribution was to note that in a system evolving via descent with modification and splitting of lineages, characters that changed state along a particular lineage can serve to indicate the prior existence of that lineage, even after further splitting occurs. The "Hennig Principle" follows from this: homologous similarities among organisms come in two basic kinds, synapomorphies due to immediate shared ancestry (i.e., a common ancestor at a specific phylogenetic level), and symplesiomorphies due to more distant ancestry (fig. 1, below). Only the former are useful for reconstructing the relative order of branching events in phylogeny -- "special similarities" (synapomorphies) are the key to reconstructing truly natural relationships of organisms, rather than overall similarity (which is an incoherent mixture of synapomorphy, symplesiomorphy, and non-homology). We must pay close attention to both ontology and epistemology, and the feedback relationship between the two: A given method makes sense only if the world really is a certain way, yet the view we have of how the world is organized is dependent on the methods we have used. For example, if species on earth are related genealogically and evolution is mainly by descent with modification (in a primarily diverging mode), then the Hennig Principle is the best method for reconstructing the history of life. Yet, the discovery of hierarchically nested characters is the best evidence we have on how evolution has occurred. 2. Homology, or When are two things the same? These concerns are relevant to characters as well; the mere act of stating that two things are the same, or parts of two things are the same, is loaded with a (perhaps subconscious but nonetheless real) complex theoretical framework. "Homology" -- One of the most important concepts in systematics, but also one of the most controversial. --classes versus individuals (type/token). --classical, pre-evolutionary views (Cuvier, Owen) --nominalistic views (many botanists, pheneticists) --the need for ontology. --evolutionary views: historical connectedness. --synapomorphy (Patterson, Stevens) --historical continuity of information (Van Valen, Roth)**Our Ontology: --Phylogenetic Homology (between organisms) --Taxic (= synapomorphy) --Transformational (plesiomorphy -> apomorphy) --Iterative Homology (within one organism), e.g., Serial Homology or Paralogy (in molecular data) Epistemology: How do we recognize homology? Best early codification of recognition criteria was that of Remane (See Wiley, 1981, pp. 130- 158): --position --quality of resemblance --continuance through intermediate forms Also, an important contribution of the cladists has been the explicit formulation of a phylogenetic criterion: ** a hypothesis of taxic homology of necessity is also a hypothesis for the existence of a monophyletic group ** --Therefore, congruence among all postulated homologies provides a test of any single character in question [the central epistemological advance]. --Is this circular? A digression into general concerns in the philosophy of science; reciprocal illumination. Patterson formulated these epistemological concerns in his three tests of homology: --similarity --conjunction --congruence Alignment of DNA. A certain prominent paleontologist who was at Harvard (who shall remain nameless, but his initials are S.J.G.) once proclaimed that comparisons of DNA have "solved the problem of homology." Is this true? The very simplicity of molecular characters (i.e., no ontogeny, few possible character states) actually leads to special problems with determining homology! We have essentially a one-dimensional string, although we may also have some additional dimensions added by structural constraints. Some epistemological concerns: -- mismatches vs. gaps -- gap penalty? Example: TCAGACGATTG Which is the best alignment? TCGGAGCTG [One approach: D = y + wz ] (I) TCAG-ACG-ATTG (II) TCAGACGATTG (III) TCAG-ACGATTG TC-GGA-GC-T-G TCGGAGCTG-- TC-GGA-GCTG-3. Brief introduction to parsimony In the Hennigian system, individual hypotheses of putative homology are built up on a character-by-character basis, then a congruence test (using a parsimony principle) is applied to identify homoplasies (i.e., apparent homologies that are not congruent with the plurality of characters). The fundamental assumptions of a parsimony-based approach to phylogenetic reconstruction are shown in the figure on the last page, one that we will return to at several points later on in the course when we get into tree building in a serious way. The basic assumptions for this method are five: (1) Reproduction (replication in the sense of Hull, 1980) must be occurring, to form lineages (the diachronic ancestor-descendent relationship). (2) Heritability (in the population genetic sense) must obtain, wherein particular features to be used as historical markers (characters) have discrete variants (character states empirically, transformational homologs ontologically) that show a strong correlation between parent and offspring. (3) Divergence (branching of lineages) must occur predominantly, as compared to reticulation, giving rise to patterns of taxic homologs shared among sister groups (the synchronic monophyly relationship). (4) Independence must occur among different characters; that is, no process (e.g.,


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Berkeley INTEGBI 200A - The Hennig Principle: Homology, Synapomorphy, Rooting issues

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