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UCSD BIBC 102 - Lecture

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Lecture 12Slide 2Slide 3Slide 4Slide 5Slide 6Slide 7Slide 8Slide 9Slide 10Slide 11Slide 12Slide 13Slide 14Slide 15Slide 16Slide 17Slide 18Slide 19Slide 20Slide 21Slide 22Slide 23Slide 24Slide 25Slide 26Slide 27Slide 28Slide 29Slide 30Slide 31Slide 32Slide 33Slide 34Slide 35Slide 36Slide 37Slide 38Slide 39Lecture 12•August 26, 2005•Lehninger (4th Edition), Chapter 17FATTY ACID DEGRADATION (OXIDATION)LNC Chapter 17LNC 10-1LNC 10-6LNC 10-8LNC 10-15LNC 10-16UPTAKE and DISTRIBUTION in MammalsLNC 17-1LNC 21-40ADIPOSE TISSUELNC 17-2ChylomicronLNC 21-39aStructure of an LDL particleLNC 21-39bBreakdown/Oxidation of Fatty Acids-OxidationActivationLNC 17-5LNC 17-6C14 fatty acid 7 acetyl CoA6 rounds of  oxidationLNC 17-7LNC 19-8LNC 17-9How to deal with unsaturated fatty acids:cis 3 - ordouble bond between LNC 17-10LNC 17-11How to deal with a fatty acid containing anuneven number of carbonsC3C4LNC box 17-1LNC box 17-2catalaseDegradation ofvery long chainfatty acids in the peroxisomeLNC 17-12Glyoxalate Cycle inPlantsLNC 17-13Ketone BodiesLNC Fig 17-18Conditions favoringketone body formation:depletion of OAfor gluconeogenesisacetyl-CoA becomesavailable forketone body synthesisMetabolic BiochemistryFATTY ACID SYNTHESISLNC Chapter 21LNC Fig. 21-1 the enzyme has threefunctional regions:- biotin carrier protein- biotin carboxylase- transcarboxylaseacetyl-CoA + CO2 ==> malonyl-CoALNC Fig. 21-4acyl carrier proteinLNC Fig. 21-2End of lecture 12August 26,


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UCSD BIBC 102 - Lecture

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