PowerPoint PresentationImmunoglobulins.Slide 3Slide 4ABSTRACT antibodyEarly history…The molecule:Slide 8Put proteins in space…Put immunoglobulins in spacePut immunoglobulins in two dimensionsSlide 12Slide 13Slide 14Slide 15Amino acid composition of CDR’sSlide 17Wu-Kabat plot:Slide 19IMMUNOLOGYBios 328a textbook-based study of immunologySpring 2003http://www.lehigh.edu/~sk08/Courses/Bios328/mainpage.htmImmunoglobulins.Immunoglobulins.-globulinsnot globinsImmunoglobulins.-globulins: any of a class of simple proteins that are insoluble in pure water but are soluble in dilute salt solutions…not globins: a colorless protein derived by removal of a heme from a conjugated proteinABSTRACT antibodyEarly history…The molecule:The molecule:Put proteins in space…Put immunoglobulins in spacePut immunoglobulins in two dimensionsPut immunoglobulins in spacePut immunoglobulins in spaceRibbon model…Put immunoglobulins in spaceSpace filling model…Put immunoglobulins in spaceDomain model…Amino acid composition of CDR’sPut immunoglobulins in space A bread and butter sandwich held together with a toothpickWu-Kabat plot:Wu-Kabat plot:Examples:The lowest ratio:Wu-Kabat index = 1 = 1/1The highest ratio:Wu-Kabat index = 400 = 20/0.05A characteristic ratio for a CDR:Wu-Kabat index = 50 = 10/0.2 = 80 =
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