Amino AcidsSlide 2Slide 3Slide 4Properties of Amino AcidsSlide 6Slide 7Slide 8Slide 9Slide 10Slide 11Separations of Amino AcidsSlide 13Reactions Amino Acids - Salt FormationReactions Amino Acids - DisulfideSynthesis of a peptideSlide 17Slide 18Amino AcidsAmino AcidsAmino AcidsAmino AcidsProperties of Amino Acids•Ques. 4: Use the above structures to answer the questions below:•a. Which amino acid is most polar?•b. Which amino acid is least polar?•c. Which amino acid has an acidic side chain?•d. Which amino acid has a basic side chain?Properties of Amino Acids•Ques. 5: Use the below structures to answer the questions:•a. Which amino acid is most polar?•b. Which amino acid is least polar?•c. Which amino acid is the most polar looking at thr and ser?•d. Which amino acid is the least polar looking at asp and glu?Amino Acids•Zwitterion - acid and amine react with each other internally.Amino Acids•-> -> Increasing pH -> ->• pH << pK << pH •Acids: HA molecular A- ionic•Bases: BH+ ionic B molecularAmino Acids•-> -> Increasing pH -> ->• pH << pK << pH •Acids: HA molecular A- ionic•Bases: BH+ ionic B molecularAmino Acids•-> -> Increasing pH -> ->• pH << pK << pH •Acids: HA molecular A- ionic•Bases: BH+ ionic B molecularAmino AcidsSeparations of Amino AcidsAmino Acids•-> -> Increasing pH -> ->• pH << pK << pH •Acids: HA molecular A- ionic•Bases: BH+ ionic B molecular•Mixture of val pI = 6; asp pI = 2.8, lys pI = 9.7in a buffer at pH = 6. What is the form of each?CNCHCHCH3H3COO_+ H3valCNCHCH2CO-OOO-H3+asplysCNCHCH2H2CCH2H2CN OO-H3+H3+Reactions Amino Acids - Salt Formation•Acid + amine --> salt (acid donates H+ to amine)Reactions Amino Acids - Disulfide•2 thiols + (O) --> disulfide + HOHSynthesis of a peptide•Amine + acid --> amide + HOHSynthesis of a peptide•Amine + acid --> amide + HOHSynthesis of a peptide•Write repeating units of backbone and add side
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