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SOFT TISSUE MODELING AND MECHANICS



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Kerdok A E Socrate S and Howe R D 2004 Soft tissue modeling and mechanics 28th American Society of Biomechanics Annual Conference X CD Technologies Inc Portland OR poster 235 SOFT TISSUE MODELING AND MECHANICS Amy E Kerdok1 2 Simona Socrate1 3 Robert D Howe1 2 1 Harvard MIT Division of Health Sciences and Technology Cambridge MA Biorobotics Laboratory Harvard University Division of Engineering and Applied Sciences Cambridge MA 3 Massachusetts Institute of Technology Dept of Mechanical Engineering Cambridge MA E mail kerdok fas harvard edu 2 INTRODUCTION Although most soft tissues do not have loadbearing functions understanding their mechanical behavior is of great interest to the medical simulation diagnostic and tissue engineering fields Obtaining these properties is a formidable challenge due to soft tissue s mechanical and geometric nonlinearities multi constituent heterogeneity viscoelastic nature and poorly defined boundary conditions It has been shown that the mechanical response of soft tissues drastically change when removed from their natural environment Brown et al 2003 Ottensmeyer et al 2004 It is necessary to measure the tissue s mechanical response under in vivo conditions Several groups have made measurements in vivo Brown et al 2003 Ottensmeyer 2001 but the interpretation of these results remain to be understood because of the inability to control boundary conditions and other testing parameters Using a method to maintain a nearly in vivo environment for ex vivo tests we have measured the force displacement characteristics of whole porcine liver using a motorized indenter The results of these tests are to be interpreted using inverse finite element modeling The material parameters will be determined from a constitutive model developed for cervical tissue Febvay 2003 and adapted for the liver METHODS To obtain nearly in vivo conditions in an ex vivo state a perfusion apparatus developed by Ottensmeyer et al 2004 was used Pigs used were systemically



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