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UCLA LIFESCI 3 - lifesci3_2_syl091

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Life Science 3Introduction to Molecular BiologySummer 2009Instructor: Hung Dinh Pham, Ph.D.E-mail: [email protected] Hours: WF 2-3 pm in Boyer Hall 554Course Objective:In this course, we introduce the basic concepts in biochemistry, molecular biology and moleculargenetics (e.g. protein structure and function, DNA structure and replication, transcription, RNAprocessing and translation, recombinant DNA technology). LS3 integrates many different areas ofscience, from physics and chemistry to biology, and places special emphasis on experimentalapproaches to understanding molecular biology.General Information:Lectures•Lecture meets: MWF 9-10:50 am in Franz 1178•Lecture Textbook: Essential Cell Biology by Alberts et. al., 2009 (3th edition)•Lectures cover all of the primary course material. They should focus your reading andstudying.•Copies of lecture slides will be posted on BlackboardTM. If slides are not posted the day beforelecture (Sunday, Tuesday and Thursday) by 10:00 pm, copies of the lecture slides will be handed outduring class.•Lectures will be podcasted at http://www.oid.ucla.edu/webcasts/courses/2008-2009Discussion sections•Teaching assistants (TAs) lead the discussion sections. They are responsible for clarifyingimportant points from the lectures/readings/labs and for answering any questions you may haveabout the course material.•You are expected to attend your assigned discussion section•Each TA will have two hours of “Office Hours” per week. You are welcome to go to the officehours of any of the TAs. Their OHs and locations will be posted on Blackboard.TA Contact Information and Discussion Sections•Karen Flummerfelt: [email protected]; Discussion 2G and 2H•Michelle Kim: [email protected]; Discussion 2E and 2F•Erin McDonald: [email protected]; Discussion 2A and 2B•Asif Razee: [email protected]; Discussion 2C and 2I Contact Information•Please put “LS3 STUDENT” in the subject heading of all e-mails. E-mails without this subjectheading will be deleted. NOTE: E-mail is not an appropriate medium for long, technicalquestions—save those types of questions for discussion sections or office hours.Labs• There are five labs total—lab reports and lab quizzes will count toward your final grade in thisclass (see Grading below). It is your responsibility to purchase a LS 3 Lab Manual by Dr.Pfluegl (9th edition) and to attend your assigned lab sections.•Lab grade transfer: Students who took the course within the last academic year are allowed totransfer their previous grades from the lab portion and be exempt from attending lab sections. Allstudents in the course must take the lab portion of the final exam. Please make sure you followthe correct procedures for taking this option. The policy and sign up procedure are availableafter students log on to http://www.lsic.ucla.edu/classes/ and click on the link under“Announcements.” This must be done by Friday of the 1st week of instruction or else youwill have to attend the laboratory sections.Reading Assignments & Exams•Reading assignments are listed on the course syllabus.•You must take exams on the scheduled dates. There are noexceptions. Please check your calendars to make sure that you don’t have schedulingconflicts!Administrative Issues•For enrollment, scheduling, etc., please contact Lily Yanez or Jane Park([email protected]) in the Life Sciences Core Curriculum Office (Life Science Building,Room 2305).Grading:Your grade in this course will be determined as follows:Lab portion (20%):Lab 1-5 (The lowest score will be dropped-but not lab 3.) = 80 pointsLab-related question on Final Exam = 20 pointsLecture portion (80%):Midterm 1 (Friday, August 14, 2009, 9-10:50 am) = 100 pointsMidterm 2 (Friday, August 28, 2009, 9-10:50 am) = 100 pointsFinal Exam (Friday, September 11, 2009, 9-10:50 am) = 200 pointsTOTAL = 500 pointsLetter grades are established from a normal curve of total points following standard UCLA guidelines.Regrading Policy:•If you feel that there has been an error during the grading of your exam:1. Type on a separate piece of paper explaining the error. Attach that note to the front of theexam.2. Turn in your exam with the note to your TA or the LS3 core office within one week of thedate the graded exams were returned.3. Keep a photocopy of the exam for your own records and for studying.4. These exams will be regraded ASAP. During this process the entire exam will bereevaluated to look for errors. Thus, your score may increase or decrease.Please note that when exams are graded, they are photocopied. Every year we have one or two studentswho add to their answer before turning in their exam for regarding. Thus, every year we have one or twostudents who get to meet the Dean and then leave UCLA.Class Expectations:•Be courteous and on time.•Silence cell phones and other electronic devices. Do not answer the phone during class.•Class participation.Other Helpful Information:•Complete the assigned readings prior to each class meeting. Class meetings are designed toclarify and/or expand on your assigned readings.•The reading and work for this class should be taken seriously. All readings assigned are yourresponsibility to complete.•You are strongly urged to attend class. Shall you miss class, obtain notes from a classmate, astest material will be stressed during lectures.•Discussion is welcomed during lecture, so please feel free to ask any questions, seekclarification, etc. If you need extra help, please see me during office hours.•Attend discussion section regularly.•The midterms and final are mainly conceptual. Most of the questions will be in short answerformat.Tentative lecture course outline with assigned readingsWeek Date Topic Chapter1 M 08/03 Introduction to Molecular Biology of the Cell Chapter 1W 08/05 Chemical Foundations of Life Chapter 2F 08/07 Protein Structure and Function Chapter 4; pg. 119-1492 M 08/10 Regulation of Protein Function and Protein Analysis Chapter 4; pg. 149-168W 08/12 DNA and Chromosome Structure Chapter 5F 08/14 Midterm I3 M 08/17 DNA Replication Chapter 6; pg. 197-210W 08/19 DNA Repair and Viruses Chapter 6; pg. 211-228F 08/21 Transcription and Post-transcriptional modification Chapter 7; pg. 231-2464 M 08/24 Translation Chapter 7; pg. 246-266W 08/26 Transcriptional Controls of Gene Expression Chapter 8; pg. 269-288F 08/28 Midterm II5 M 08/31 Post-Transcriptional


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