Harvard-MIT Division of Health Sciences and Technology HST.121: Gastroenterology, Fall 2005 Instructors: Dr. Jonathan Glickman Non-neoplastic diseases of the esophagusEsophageal diverticula Image by MIT OCWZenker’s diverticulumImage removed due to copyright reasons.Esophagus- hiatal hernias Image by MIT OCWEsophagitis- classification • Reflux • Infectious: viral, fungal • Allergic • Drug-related • Physical: Radiation, pill, corrosive agents • Achalasia • Systemic disorders: Crohn’s, GVHD, sarcoidosis, sclerodermaReflux esophagitis- gross Figure removed due to copyright reasons. Please see: Rosai, Juan. Rosai and Ackerman's Surgical Pathology. 9th ed. New York, NY: Elsevier Health Sciences, 2004. ISBN: 0323013422.Active esophagitis- histology • Basal zone hyperplasia • Spongiosis • Elongated papillae (>75%) • Intraepithelial PNMs and/or eosinophils • Surface erosion or ulcerationZenker’s diverticulum Image removed due to copyright reasons.Achalasia • Unknown etiology • Defect in peristalsis and LES relaxation • Similar physiology to Chagas’ disease • Distal esophageal narrowing • Risk factor for squamous cell
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