22 Lab 2: Supporting Information – Piperine Synthesis Skills and Resources covered: • Searching SciFinder Scholar for the Registry Number for piperine. • Locating research references pertaining to piperine in SciFinder Scholar. • Formulating a research question related to piperine based on SciFinder Scholar search results. • Saving pertinent citations in SciFinder Scholar tagged output format. • Importing SciFinder Scholar citations into RefWorks, a web-based citation management tool. • Using RefWorks to print a bibliography in the ACS output style. 1. Getting Started 1. Log in to your computer using the password provided for this classroom. 2. Download Lab 2 “Supporting Information document” from the Chemistry 346 library instruction web site: www.library.wisc.edu > CAMPUS LIBRARIES > CHEMISTRY LIBRARY > LIBRARY INSTRUCTION > CHEMISTRY 346 2. Creating a RefWorks Account RefWorks is a web-based citation management tool which allows you to collect literature citations, insert citations into a research paper, and then automatically format your citations and bibliography. www.library.wisc.edu > JOURNALS, MAGAZINES AND NEWSPAPERS > REFWORKS: INFORMATION MANAGER. Log into your RefWorks account or follow instruction under “Setting up a new RefWorks account” to set up a new account. Create a new folder called Chem 346. 2. Searching SciFinder Scholar for the Registry Number for piperine SciFinder Scholar is a client-server program used to access information in selected Chemical Abstracts Service (CAS) databases: CAPlus, CARegistry, CAREACTS, CHEMCATS, and CHEMLISTS. It permits searching in a variety of ways: author name, research topic, substance identifier (CAS Registry Number, chemical name), chemical structure/substructure, or chemical reaction. You can access SciFinder Scholar from any campus library computer by going to www.library.wisc.edu > Journals, Magazines and Newspapers > “S”. SciFinder Scholar is also available in the Organic Chemistry Computer Lab. To access SciFinder Scholar from your desktop, you must install the23 client on your personal computer. Contact Emily if you want to install SciFinder Scholar on your personal computer. Caution: The UW-Madison Libraries’ SciFinder Scholar license permits only 7 simultaneous users across campus. Consequently you may not be able to access SciFinder Scholar during busy times of the day. The Chemical Abstracts Service Registry Number (CAS RN) is a unique, three-part identifier assigned to each compound indexed in CA. For example, the RN for acetic acid is 64-19-7. The Registry Number is also useful for searching your compound in many other online databases and printed indexes. 1. Launch SciFinder Scholar from the START menu. 2. Click on CHEMICAL SUBSTANCE OR REACTION in the EXPLORE window. 3. Search for piperine as “Substance identifier” or use the structure editor to draw piperine. 4. Click OK to search and display the CAS Registry file results. 5. Click on the MICROSCOPE icon to view the piperine Registry File record. Here you will find the Registry Number, formula, CA index names, calculated and some experimental properties. Some Registry File records also include links to commercial source, regulated list, and reactions. 3. Locating research references pertaining to piperine in SciFinder Scholar Chemical Abstracts (CA) is produced by the Chemical Abstracts Service (CAS), a division of the American Chemical Society. It was first published in 1907. It attempts to index every publication type (articles, books, patents, proceedings, etc.) in all languages from all areas of the chemical sciences. It is the most comprehensive index to the chemical literature in the world. 1. From the piperine Registry record, click on GET REFERENCES. 2. Click on ALL. You should have ~600+ references.24 4. Formulating a research question related to piperine based on SciFinder Scholar search results. Identifying a research topic is often the most difficult part of writing a research paper. SciFinder Scholar can help you narrow your results in two ways: Role, and Analyze/Refine. To use Role, use the BACK button to return to the CAS Registry window where you clicked on GET REFERENCES. Select a specific role of interest (e.g. Adverse Effects). To use ANALYZE/REFINE, refine your search to English language references. Use Analyze by CA section or Index Term to select results on a subtopic of interest. After exploring several references, formulate a research topic question and record that question plus useful CA Section titles/index terms in “Lab 2 Supporting Information”. 5. Saving pertinent citations in SciFinder Scholar tagged output format. In order to import citations into a personal citation manager like RefWorks, records must be formatted in a certain way. To import SciFinder Scholar records into RefWorks, the records must be in tagged format. See “Instructions for Moving Citations into RefWorks” (http://www.library.wisc.edu/instruction/refworks/importing.htm) for other vendors and databases. (1) SELECT a minimum of 15 references in your SciFinder Scholar search results that are pertinent to your research topic. (2) Click on SAVE AS. (3) Select TAGGED FORMAT (*.TXT) for file type. (4) Name the file with a .txt extension. (5) SAVE to the desktop. (6) Upload this file to your WebSpace for future use. Please EXIT SciFinder Scholar when you are finished working in the database. 6. Importing SciFinder Scholar citations into RefWorks, a web-based citation management tool. There are four ways to bring citations into your RefWorks account: (1) Searching an online database from within RefWorks (like MadCat). (2) Manually typing a new reference. (3) Direct import for certain databases like Academic Search, ProQuest Research Library, and Engineering Index. (4) Using an import filter.25 For more information about transferring records, see “Instructions for Moving Citations Into RefWorks” (http://www.library.wisc.edu/instruction/refworks/importing.htm). RefWorks requires a filter to import SciFinder Scholar records. (1) Login to your