View Full Document

Genomic Selection using Low-Density SNPs



View the full content.
View Full Document
View Full Document

7 views

Unformatted text preview:

Faculty of Agriculture and Nutritional Science Christian Albrechts University of Kiel Institute of Animal Breeding and Husbandry Genomic Selection using Low Density SNPs David Habier Napapan Pyiasatian Jack Dekkers Rohan Fernando Habier et al 2009 Genetics 182 343 353 Genomic selection Meuwissen et al 2001 Genetic Evaluation using high density SNPs Phenotype 0 8 0 7 Genotype 0 6 3 4 5 6 Generation 7 8 for 50 000 SNPs Genotype for 50 000 SNPs Training data Accuracy 1 0 9 Estimate marker effects Predict BV from marker genotypes at early age Predict BV Genotype for 50 000 SNPs from marker genotypes at early age 1 Introduction Implementation of GS Original principle of Genomic Selection GS High density HD SNP genotypes used for both Estimation of marker effects training Prediction of GS EBV for selection candidates Not feasible for many species Need Low 380 vs High density panel for routine implementation 50 vs 250 per animal Standard approach to developing Low density panels Select the best SNPs from the HD panel Trait and population specific Proposed approach use well spaced Low density SNP genotypes3on selection candidates to fill in missing HD SNP genotypes Outline Introduction What is ELD GS Methods Published results Unpublished results Criteria for loss of accuracy Factors affecting loss of accuracy of ELD GS Precision of PDMs Simulations Results Conclusions outlook 4 2 Concept of Low Density Genomic Selection paternal maternal Sire s LDLD GS paternal maternal Progeny i LDLD GS paternal maternal Dam d HD GS EBVi g LD GS EBVi p m SNP k SNP k p ik g ik Sum estimates of effects of maternal and patern al paternal SNP alleles m p gdk pikpdgdk pms gm pikpsgpsk ik sk md ik 5 Probability that i received dam dam s maternal allele at SNP k Methods LDLD GS Progeny i paternal maternal LDLD GS Steps of proposed low density genomic selection method 1 Estimate marker allele effects of HD SNPs Bayes B 2 Infer HD SNP haplotypes of training individuals Requires parental HD SNP



Access the best Study Guides, Lecture Notes and Practice Exams

Loading Unlocking...
Login

Join to view Genomic Selection using Low-Density SNPs and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view Genomic Selection using Low-Density SNPs and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?