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Antibody Blood Tests Researchers have discovered that people with celiac disease who eat gluten have higher than normal levels of certain antibodies in their blood Antibodies are produced by the immune system in response to substances that the body perceives to be threatening Think of antibodies as a sending out a warning signal to the body only in the case of an autoimmune disorder like celiac disease the warning signal sounds for something that is supposed to be safe the proteins in wheat rye and barley that are generically known as gluten Antibody Testing Only A First Step To help diagnose celiac disease physicians first test blood to measure levels of certain antibodies These antibodies are anti endomysium and anti tissue transglutaminase A positive antibody test indicates only that a person needs a biopsy it is not a diagnosis in and of itself Antibody tests measure your immune system s response to gluten in the food you eat Your doctor may order a panel of tests to aid in diagnosis or order one or several to see if you may need further evaluation The blood for these tests are usually sent to one of only a few labs in the country that are best suited for conducting the test and interpreting the results These laboratories include Prometheus Labs Quest Diagnostics and the Mayo Clinic Which tests do I need If my positive antibody test suggests I may have celiac disease how do I find out for sure If antibody tests and or symptoms suggest celiac disease the physician needs to establish the diagnosis by obtaining tiny pieces of tissue from the small intestine to check for damage to the villi This is done in an endoscopic biopsy procedure The physician eases a long thin tube called an endoscope through the mouth and stomach into the small intestine and then takes samples of the tissue using instruments passed through the endoscope Biopsy of the small intestine is the only way to diagnose celiac disease Why is it necessary to have the endoscopic biopsy It is important

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