View Full Document

NSAIDS - non-salicylates



View the full content.
View Full Document
View Full Document

4 views

Unformatted text preview:

NSAIDS n o n salicylates Sandra P Welch Ph D Professor Pharmacology Toxicology Learning Objectives 1 Learn the main differentiating property use or side effect for the nonsteroidal aspirin substitutes S m i t h 7 3 4 8 2 8 8 4 2 4 s w e l c h h s c v c u e d u 2 Understand concerns for toxicity of NSAIDs in those with compromised renal or liver function I General Use A 1 2 3 4 Similarities to aspirin a n t i i n f l a m m a t o r y i n h i b i t P G s y n t h e s i s analgesic antipyretic antithrombotic B T h e y d i f f e r f r o m a s p i r i n i n t h a t they m a y 1 produce fewer or more side effects 2 have greater tissue distribution 3 be more potent and 4 have a longer duration Unlike aspirin they are reversible i n h i b i t o r s o f c y c l o o x y g e n a s e TOXICITY CONCERNS Individuals who are allergic to aspirin will be allergic to other NSAIDs that inhibit cyclooxygenase Some NSAID aspirin substitutes produce fewer side effects compared to ASA e g selective COX 2 inhibitors less stomach upset N S A I D s c a n decrease G F R i n t h o s e w i t h renal failure congestive heart disease or cirrhosis of the liver NSAIDs can produce idiosyncratic interstitial nephritis in a small population who are simply allergic to the NSAID NSAIDs should be used with caution in individuals with reduced renal or liver function 1 Older patients may also have fluid retention Also NSAIDs can complicate antihypertensive therapy exacerbating heart failure and hypertension The elderly also have a significantly higher rate of in some patients they can decrease renal function and excretion which tends to increase blood pressure N S A I D i n d u c e d G I b l e e d i n g c o m p a r e d t o a g ematched controls not receiving NSAIDs and often are asymptomatic Additionally memory loss The elderly may quickly develop impaired renal function from NSAIDs and other cognitive impairments occasionally occur in the elderly Ranking of NSAIDs on Basis of Adverse MORTALITY DATA FOR SEVEN



Access the best Study Guides, Lecture Notes and Practice Exams

Loading Unlocking...
Login

Join to view NSAIDS - non-salicylates and access 3M+ class-specific study document.

or
We will never post anything without your permission.
Don't have an account?
Sign Up

Join to view NSAIDS - non-salicylates and access 3M+ class-specific study document.

or

By creating an account you agree to our Privacy Policy and Terms Of Use

Already a member?