Slide 1Slide 2Slide 3Slide 4Slide 5Slide 6Discovering New Drug-Drug InteractionsBy Text-Mining the Biomedical LiteratureBeth PerchaCS 224NFinal ProjectMarch 17, 2011Background●Americans are on a lot of drugs.●Drug interactions are bad.●We don't test for them in clinical trials.●We need ways to find likely interactions so we can watch out for them.Methods (I)Start with indexed version of Medline:17 million abstracts88 million sentencesTwo lexicons:Genes (43 VIP genes)Drugs (602; at least one interaction)ANDMethods (II)Results (I)Results (II)Most likely interactions...Least likely
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