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UCLA LIFESCI 3 - Syllabus

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Life Science 3Introduction to Molecular BiologySummer 2010Instructor: Hung Dinh Pham, Ph.D.E-mail: [email protected] Hours: M 7:15-8:15, W 2:30-3:30, and F 10:30-11:30 in Boyer Hall 554Course Objective:In this course, we introduce the basic concepts in biochemistry, molecular biology and moleculargenetics (e.g. protein structure and function, DNA structure and replication, transcription, RNAprocessing and translation, recombinant DNA technology). LS3 integrates many different areas ofscience, from physics and chemistry to biology, and places special emphasis on experimentalapproaches to understanding molecular biology.General Information:Lectures•Lecture meets: MWF 8:30-10:20 in Franz 1178•Lecture Textbook: Cell and Molecular Biology by Gerald Karp (6th edition)•Lectures cover all of the primary course material. They should focus your reading andstudying.•Lecture slides will be posted on BlackboardTM at www.lsic.ucla.edu/classes/summer10/. Ifslides are not posted the day before lecture (Sunday, Tuesday and Thursday) by 10:00 pm, copies ofthe lecture slides will be handed out during class.•Lectures will be webcasted at http://www.oid.ucla.edu/webcasts/courses/2009-2010Discussion sections•Teaching assistants (TAs) lead the discussion sections. They are responsible for clarifyingimportant points from the lectures/readings/labs and for answering any questions you may haveabout the course material.•You are expected to attend your assigned discussion section•Each TA will have two hours of “Office Hours” per week. You are welcome to go to the officehours of any of the TAs. Their OHs and locations will be posted on Blackboard.TA Contact Information•Adi Avital: [email protected]•Erin McDonald: [email protected]• James Huang: [email protected]•Asif Razee: [email protected] Contact Information•Please put “LS3 STUDENT” in the subject heading of all e-mails. E-mails without this subjectheading will be deleted. NOTE: E-mail is not an appropriate medium for long, technicalquestions—save those types of questions for discussion sections or office hours.Labs• There are five labs total—lab reports and lab quizzes will count toward your final grade inthis class (see Grading below). It is your responsibility to purchase a LS 3 Lab Manual by Dr.Pfluegl (10th edition) and to attend your assigned lab sections.•Lab grade transfer: Students who took the course within the last academic year are allowed totransfer their previous grades from the lab portion and may be exempt from attending labsections. All students in the course must take the lab portion of the final exam. Please makesure you follow the correct procedures for taking this option. The policy and sign upprocedure are available after students log on to http://www.lsic.ucla.edu/classes/ and clickon the link under “Announcements.” This must be done by Friday of the 1st week ofinstruction or else you will have to attend the laboratory sections.Reading Assignments & Exams•Reading assignments are listed on the course syllabus and will be updated at the beginning ofeach lecture.•You must take exams on the scheduled dates. There are noexceptions. Please check your calendars to make sure that you don’t have schedulingconflicts!Administrative Issues•For enrollment, scheduling, etc., please contact Lily Yanez or Jane Park([email protected]) in the Life Sciences Core Curriculum Office (Life Science Building,Room 2305).Grading:Your grade in this course will be determined as follows:Lab portion (20%):Lab 1-5 (the lowest score will be dropped-Not lab 3) = 80 pointsLab-related question on Final Exam = 20 pointsLecture portion (80%):Midterm 1 (Friday, July 2, 2010, 8:30-10:20 am) = 100 pointsMidterm 2 (Friday, July 16, 2010, 8:30-10:20 am) = 100 pointsFinal Exam (Friday, July 30, 2010, 8:30-10:20 am) = 200 pointsTOTAL = 500 pointsLetter grades are established from a normal curve of total points following standard UCLA guidelines.Regrading Policy:•If you feel that there has been an error during the grading of your exam:1. Type a note on a separate piece of paper explaining the error. Attach that note to the front ofthe exam.2. Turn it your exam with the note to your TA or the LS3 core office within one week of thedate the graded exams were returned.3. Keep a photocopy of the exam for your own records and for studying.4. These exams will be regraded ASAP. During this process the entire exam will bereevaluated to look for errors. Thus, your score may increase or decrease.Please note that when exams are graded, they are photocopied. Every year we have one or two studentswho add to their answer before turning in their exam for regarding. Thus, every year we have one or twostudents who get to meet the Dean and then leave UCLA.Class Expectations:•Be courteous and on time.•Silence cell phones and other electronic devices. Do not answer the phone during class.•Class participation.Other Helpful Information:•Complete the assigned readings prior to each class meeting. Class meetings are designed toclarify and/or expand on your assigned readings.•The reading and work for this class should be taken seriously. All readings assigned are yourresponsibility to complete.•You are strongly urged to attend class. Shall you miss class, obtain notes from a classmate, astest material will be stressed during lectures.•Discussion is welcomed during lecture, so please feel free to ask any questions, seekclarification, etc. If you need extra help, please see me during office hours.•Attend discussion section regularly.•The midterms and final are mainly conceptual.Tentative lecture course outlineWeek Date Topic Chapter1 M 06/21 Introduction to Molecular Biology of the Cell Chapter 1W 06/23 Chemical Foundations of Life Chapter 2F 06/25 Protein Structure and Function Chapter 22 M 06/28 Bioenergetics Chapter 3W 06/30 DNA and Chromosome Structure Chapter 10 (pg. 379-392)F 07/02 Midterm I3 M 07/05 HolidayW 07/07 Transcription Chapter 11F 07/09 Translation Chapter 114 M 07/12 Transcriptional Control of Gene Expression Chapter 12W 07/14 Post-Transcriptional Control Chapter 12F 07/16 Midterm II5 M 07/19 DNA Replication Chapter 13W 07/21 DNA Repair Chapter 13F 07/23 Genomics Chapter 10 (pg. 393-418)6 M 07/26 Molecular Techniques I Chapter 18W 07/28 Molecular Techniques II Chapter 18F 07/30 Final


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