Brandeis BCHM 151 - Structure and Mechanisms in Membrane Transport Proteins (2 pages)

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Structure and Mechanisms in Membrane Transport Proteins



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Structure and Mechanisms in Membrane Transport Proteins

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2
School:
Brandeis University
Course:
Bchm 151 -

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Biochemistry 151 Structure and Mechanisms in Membrane Transport Proteins Instructor Chris Miller This is an advanced topics seminar course that will meet Mondays 2 5PM It will be conducted exclusively with primary literature readings Each week will be aimed at a particular topic in this field Papers for each week s discussion will be posted several weeks in advance PDFs of these papers will be available on the Brandeis CT course website Course webpage All class materials except for PDF files are available on an open webpage at http www bio brandeis edu classes biochem151a Literature readings All students are expected to be familiar with all the assigned readings and to present various aspects of these readings when called upon to do so Readings will not be assigned each week to particular students for presentation instead all students must come to class prepared to present and to discuss the readings PDFs can be downloaded at http webct brandeis edu Molecular graphics Nearly all the topics to be discussed will have associated with them high resolution crystal structures Students must obtain the pdb files of these structures from an appropriate database and view these while reading papers about the proteins A superb database devoted solely to membrane protein structures has been constructed by Steve White at UC Irvine http blanco biomol uci edu Membrane Proteins xtal html There are many molecular graphics programs available I use RasMol because of its simplicity This program is installed on the Brandeis library computers and may be downloaded from the web for free http www rasmol org I have written a stripped down RasMol tutorial which you can access on the course webpage Schedule of Class Meetings Monday 2 5 PM Kosow 116 Sep 8 Organization lecture on basic principles of membrane transport Sep 15 Structure of lipid bilayer membranes membrane peptide interaction Sep 22 NO CLASS Sep 29 Architecture and folding thermodynamics of helical integral membrane proteins Oct 7



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