Slide 1Inflammatory ResponseAnti-inflammatory AgentsTypes of Anti-inflammatory AgentsSalicylates- NSAIDNSAIDsCommon SalicylatesNSAIDs IndicationsContraindications to NSAIDsSlide 16Slide 17Slide 19MnemonicsMnemonicsMnemonicsMnemonics- photosensitivityMnemonics- ototoxicity /peak and troughMnemonics and study aidsANTI-INFLAMMATORY MEDSMegan Rohm, BSN, RNINFLAMMATORY RESPONSEProtects the body from injury and pathogensUses chemical mediators to produce the reaction that helps destroy pathogens and promote healingANTI-INFLAMMATORY AGENTSBlock or alter the chemical reactions associated with the inflammatory responseTYPES OF ANTI-INFLAMMATORY AGENTSCorticosteroids: used systemically to block the inflammatory and immune systemsAntihistamines: block the release of histamine in the initiation of the inflammatory responseNSAIDSSALICYLATES- NSAIDCan block the inflammatory responseHave antipyretic (fever-blocking) propertiesHave analgesic (pain-blocking) propertiesNSAIDSProvide strong anti-inflammatory and analgesic effectsSold over the counter, which may lead to abuseCOMMON SALICYLATESAspirin (Bayer,etc.): treats inflammatory conditionsBalsalazide (Colazal): new drug that treats ulcerative colitisCholine magnesium trisalicylate (Trilisate): treats mild pain and fevers as well as arthritisCholine salicylate (Arthropan): treats mild pain and fevers as well as arthritisMesalamine (Pentasa, etc.): treats inflammation of the large intestineOlsalazine (Dipentum): converted to mesalamine in the colon; has the same direct anti-inflammatory effectsSalsalate (Argesic, etc.): treats pain, fever, and inflammationSodium thiosalicylate (Rexolate): treats episodes of acute gout and muscular pain as well as rheumatic feverNSAIDS INDICATIONSRelief of the signs and symptoms of rheumatoid arthritis and osteoarthritisRelief of mild to moderate painTreatment of primary dysmenorrheaFever reductionCONTRAINDICATIONS TO NSAIDSPresence of allergy to any NSAID or salicylateCardiovascular dysfunction or hypertensionPeptic ulcer or known GI bleedingPregnancy and lactationCaution with renal or hepatic dysfunctionMNEMONICS NSAIDSNo alcoholSide effects (teach them to report any dark tarry stools, coffee-ground or bloody emesis, GI distress, tinnitus) ASA sensitivity - do not giveIbuprofen, indocin are a few examplesDo take with foodStop 5-7 days before surgeryMNEMONICS Empty stomachPenicillin Sulfa drugs TetracyclineMNEMONICS Antacids- FaCTFluoroquinolone a Cephalosporins TetracyclinesMNEMONICS- PHOTOSENSITIVITY Terrible Fucking SunburnTetracycline Fluroquinolines SulfonamidesMNEMONICS- OTOTOXICITY /PEAK AND TROUGH Audio Visualm aI nn co og ml yy cc io nsIdeMNEMONICS AND STUDY