CHEM 6304 Section 5731Biomembranes: Structure and BiophysicsMeets: M W F 8th Period MAT 0005Exam 4A3 credit courseRecommended Texts:Biomembranes: Molecular Structure and FunctionRobert B. GennisThe Structure of Biological MembranesPhilip L. YeaglePLEASE DO NOT RECALL BOOKS FROM THE LIBRARY. THE HEALTH SCIENCE LIBRARY HAS 1 COPY OF EACH BOOK. PLEASE SHARE THE TEXTS, OTHERWISE I WILL BE FORCED TO PUT THEM ON RESERVE.Semester Holidays (and other days off)Jan 16th - M – Martin Luther King DayFeb 20-24th – (Biophysical Society Meeting, Salt Lake City, Utah)March 13th-17th – Spring BreakApril 12th (room occupied)Grading:20% Class Participation30% In-class presentations (depending upon enrollment, 1-2 30 minute presentations)25% Midterm (in-class)25% Final (in-class)Midterm is scheduled for Friday, March 10th.Schedule for student presentations. All student presentations will occur during the Friday lecture period. Students will be graded by me as well as one another. I will have an evaluation sheet that each registered student will complete per presentation. You will NOT put your name on the sheet, but a code that only I will recognize. The presenter will get all feed backfrom evaluations. In this manner, the presenter will not know who gave what review, but I will. Asignificant part of your in-class participation grade will come from the questions that you ask of the presenter.The presentations will be focused on a topic and a technique. The presenter can choose a current paper from the literature or from a text or review article. The purpose(s) of this exercise are (1) topresent more current information than is in the recommended texts, (2) to practice public speaking, (3) to promote group learning, and (3) to learn how to critically read the literature. The time for each presentation is only 25 minutes so you must be focused.The presenter is required to pass out any pertinent literature (first cleared by me), 1 week prior to the presentation. Failure to meet this 1 week deadline will result in a 20% deduction of the grade for the presentation.The following is a list of journals that you may find useful in locating an interesting article to present. The other method that I recommend for finding an interesting article is to look at the authors of the chapters in the texts we are using and to find one of their more current articles. Have fun!Chemistry and Physics of LipidsBiochimica et biophysica acta. BiomembranesBiochimica et biophysica acta. Lipids and lipid metabolism LangmuirBiophysical JournalBiochemistryNature Structural BiologyJournal of Physical ChemistryProceedings of the National Academy of SciencesThe following is a recommended list of topics with presentation dates. The goal is to have the presentation topics relate to current lecture presentations. I will introduce most topics and techniques in lecture. Your job is to give a clear, thorough example of a recent application in the literature. Week # Date Topic/Technique Presenter 1 Presenter 23Jan 27Lipid mesophasesDSC/NMR /X-ray4Feb 3Detergent-lipid phasesDynamic light scatteringLidia Kulemina5Feb 10Anesthetics-small molecule partitioningEPR /NMRMandy BlackburnFunda Tongay6Feb 17Cholesterol/lipid raftsFluorescence :FRET/FRAP etcWarren Mino Heather Kerstner8Mar 3Membrane Enzymes/Lipid AssymmetryAssays/chemical modificationAhu Demir11Mar 24Antibiotic peptides/cell penetrating peptidesIsothermal titration calorimetryJamie Kear12Mar 31Membrane proteins- channels/poresStructure-reconstitutionDanyell Wilson Mandi Hartman13Apr 7Membrane proteins receptors/signal transductionCaroline Keenan Yanrong Wu14Apr 14Membrane fusion/membranecurvatureEPR/fluorescenceGeorge Okeyo15Apr 21Lipid phases for crystallization/ x-rayPlease sign up for 2 slots (so far 10 people registered). The topics can be varied but must first be cleared by
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