MIT 20 441J - UNIT CELL PROCESSES ASSOCIATED WITH WOUND HEALING (34 pages)

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UNIT CELL PROCESSES ASSOCIATED WITH WOUND HEALING



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UNIT CELL PROCESSES ASSOCIATED WITH WOUND HEALING

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Pages:
34
School:
Massachusetts Institute of Technology
Course:
20 441j - Biomaterials-Tissue Interactions

Unformatted text preview:

Massachusetts Institute of Technology Harvard Medical School Brigham and Women s Hospital VA Boston Healthcare System 2 79J 3 96J 20 441 HST522J UNIT CELL PROCESSES ASSOCIATED WITH WOUND HEALING M Spector Ph D Acute Chronic Photos and diagrams of skin wound healing removed due to copyright restrictions WOUND HEALING Roots of the Tissue Response Resolution Slight Nonvascularized tissue No Healing Injury Inflammation Vascularized tissue 4 Tissue Categories Connective Tissue Epithelium Nerve Muscle Healing Process Regeneration CT bone Ep epidermis Muscle smooth spontaneous Repair Scar CT cartilage Nerve Muscle cardiac skel RESPONSE TO IMPLANTS WOUND HEALING Injury Vascular Response Inflammation Tissue of Labile and Stable Cells Framework Framework Intact Destroyed Regeneration Scar Tissue of Permanent Cells Scar RESPONSE TO IMPLANTS WOUND HEALING Surgical Implantation Acute Inflammation Vascular Response Clotting Phagocytosis Neovascularization New Collagen Synthesis Tissue of Labile and Stable Cells Inc time Granulation Tissue Tissue of Permanent Cells Implant Movement Framework Framework Intact Destroyed Regen Scarring incorp fibrous encapsulation of implant synovium Chronic Inflammation Scarring fibrous encapsulation synovium Chronic Inflammation Acute Inflammation Local Gross Changes The cardinal signs of acute inflammation are Redness Heat Swelling Pain Loss of function Granulation Tissue Photo removed due to copyright restrictions UNIT CELL PROCESSES Regulator UCP Cell Matrix Connective ECM Tissue Adhesion Epithelia Protein Muscle Collagen Nerve Biomaterial Integrin Product Regulator Mitosis Synthesis Migration Contraction Endocytosis Exocytosis UNIT CELL PROCESSES VASCULAR RESPONSE Diagrams removed due to copyright restrictions Contraction Endothelial Cell Basal Lamina Leakage Reg UNIT CELL PROCESSES VASCULAR RESPONSE circulation Exocytosis Platelet serum Seratonin PAF circulation Exocytosis Basophil serum tissue Reg Reg Exocytosis Mast Cell ECM Reg Seratonin



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