MARIETTA BIOL 309 - Recent advances in melanoma research (13 pages)

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Recent advances in melanoma research



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Journal of Dermatological Science 26 2001 1 13 www elsevier com locate jdermsci Review article Recent advances in melanoma research Toshiaki Saida Department of Dermatology Shinshu Uni6ersity School of Medicine 3 1 1 Asahi Matsumoto 390 8621 Japan Received 14 December 2000 accepted 18 December 2000 Abstract Recent advancement in the research of malignant melanoma is reviewed Among many gene alterations detected in human melanoma defect of CDKN2A located at chromosome 9p21 seems to be most important in the earlier developmental phase though significance of this gene in the evolution of melanoma in situ has not been confirmed yet Deletions of PTEN MMAC1 on 10q23 3 and AIM1 on 6q21 as well as mutations of ras gene are involved in the later progression stages of melanoma Adhesion molecules relevant to development and progression of melanoma have been intensely investigated in recent years revealing crucial roles of cadherins and avb3 integrin in the biologic behaviors of melanoma cells Melanoma is characterized by extremely high potential of developing metastases Dynamic changes of matrix metalloproteinase activity during invasion and movement of melanoma cells may be a major concern in this field Fragility of blood vessels in melanoma lesions is another important point related to hematogeneous metastases Acral lentiginous melanoma is a unique subtype of melanoma because in contrast to other subtypes ultraviolet irradiation is not a major factor in its development Investigation of pathogenesis of acral lentiginous melanoma surely provides us with new information about mechanism of melanocyte transformation Recent advances in the management of malignant melanoma are also briefly reviewed such as biochemotherapy immunotherapy and gene therapy Finally the concept of molecular classification of melanoma by gene expression profile is introduced which possibly enables us to give the tailor made therapy for each melanoma patient in the near future 2001 Elsevier Science Ireland



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