UI PSYC 372 - G-Protein Receptors (4 pages)

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G-Protein Receptors



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Psyc 372 Physiological Psychology Background Consist of three subunits G Protein Receptors Alpha Beta Gama Guanine Nucleotide Binding Proteins Psychology 372 Physiological Psychology Steven E Meier Ph D Listen to the audio lecture while viewing these slides 1 2 Psyc 372 Physiological Psychology Psyc 372 Physiological Psychology Alpha Family Group Contains Is loosely associated with the membrane Is usually the coupling agent between receptors and primary effector enzymes Have more than 12 types Each has different action and name Alpha and Beta adrenergic receptors Muscarinic Ach receptors GABAb Receptors Certain Glutamate receptors Certain Serotonin Receptors Neuropeptide Receptors Odorant Receptors Rhodopsin Others 3 4 Psyc 372 Physiological Psychology Psyc 372 Physiological Psychology Beta Gamma Complex Other Important Structures Is more tightly fixed to the membrane Can also affect ion channels directly 5 6 1 Psyc 372 Physiological Psychology Psyc 372 Physiological Psychology Adenylyl Cyclase AC Protein Kinases Is activated by the Alpha subunit Have four subunits Two Regulatory Subunits When activated makes cAMP from ATP Alpha Binding Site Where cAMP binds ATP Two Catalytic Subunits R R C C Puts phosphate groups on ion channels Is the working part of the enzyme cAMP cAMP is an intracellular messenger cAMP 7 External Signal First Messenger NT Psyc 372 Physiological Psychology 8 Psyc 372 Physiological Psychology G Proteins At Rest RECEPTOR BINDING SITE XXXXXXXXXXXXXXXXX Receptor Transducer GDP Primary Effector Second Messenger Secondary Effector GTP Binding Site GTP is converted to GDP 9 GDP occupies the binding site when the receptor is at rest Psyc 372 Physiological Psychology Psyc 372 Physiological Psychology What Happens Stimulation begins Stimulation NT causes a conformational change and knocks off GDP Result Leaves Alpha binding site open GDP Leaves NT XXXXXXXXXXXXXXXXX 11 10 12 2 Psyc 372 Physiological Psychology Psyc 372 Physiological Psychology Open Binding Site GTP binds to the open binding site NT NT XXXXXXXXXXXXXXXXX Open binding site XXXXXX GTP 13 Psyc 372 Physiological Psychology 14 Psyc 372 Physiological Psychology Conformation Change Adenylyl Cyclase AC Causes a conformational change Is activated by the Alpha subunit NT Get Dissociation When activated makes cAMP from ATP Alpha Binding Site XXXXXX GTP 15 cAMP is an intracellular messenger ATP cAMP Psyc 372 Physiological Psychology Psyc 372 Physiological Psychology Note Kinases s binds on AC When it binds it becomes GTPase GTPase s convert GTP to GDP When converts to GDP it breaks the bond from AC Then rebinds with the beta subunits At same time NT is being removed from the receptor binding site Alpha and Beta s then link to the receptor site Repeat the process Kinases put phosphate groups on something Where A protein Ion Channel Result Protein Kinase Many types of PK 17 16 CAMP Protein Kinase CaCal Protein Kinase Protein Kinase C Others 18 3 Psyc 372 Physiological Psychology Protein Kinases Has four subunits Two Regulatory Subunits Where enzymes cAMP binds Two Catalytic Subunits cAMP R R C C Puts phosphate groups on ion channels Is the working part of the enzyme 19 4


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