UCLA HNRS 70A - HC70A-W11-2-10-11-Lecture5-6 (118 pages)

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HC70A-W11-2-10-11-Lecture5-6



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HC70A-W11-2-10-11-Lecture5-6

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Pages:
118
School:
University of California, Los Angeles
Course:
Hnrs 70a - Genetic Engineering in Medicine, Agriculture, and Law

Unformatted text preview:

HC70A SAS70A Winter 2011 Genetic Engineering in Medicine Agriculture and Law Professors Bob Goldberg John Harada Lectures 5 6 The Age of Genomics Your Personal Genome Tracing Your Ancestry Course Administratorp THEMES 1 Two Genomes in a Cell 2 What is the Mitochondrial Genome and How is it Inherited 3 What Are the Characteristics of the Human Genome 4 The Age of the Personal Genome Has Arrived 5 How Many Mammalian Genomes Have Been Sequenced and What Can We Learn From Comparative Genomics 6 How Does Genetic Variation Arise in the Human Genome 7 How to Use DNA Markers to Find Human Disease Gene Alleles 8 How to Detect DNA Sequence Variation SNPs and VNTRs 9 What Can SNPs Be Used For 10 Tracing Human Ancestry Using SNPs 11 Are Their Human Races 12 Knowledge or Certainty Human Cells Have Two Genomes One in the Nucleus and One in the Mitochondria Do Nuclear Mitochondrial Genes Have Different Inheritance Patterns The Nuclear and Mitochondrial Genomes in Size Shape Nuclear 3 2 Mb 25 000 Genes 24 Linear Pieces Mitochondrial 17 kb 30 Genes 1 Circle The Nucleus Is A Complex Organelle With 23 Pairs of Chromosomes Humans Packing Problem RNA Protein Transport The Human Genome End to End is 1 1 Meters in Length Note Chromosome Sizes Bands Markers The Human Karyotype 3 2 x 109 bp 3 2 Mb Note Chromosome Sizes Bands Markers The Mitochondrial Genome Mitochondria Power Human Cells and Contain a Circular Genome Makes ATP Energy That Powers All Cells Semi Autonomous Genome DNA Divides Transcription Translation Mitochondrial Proteins Mitochondrial DNA Diseases Affect 1 400 People MERRF A Mitochondrial Disease Example No Mitochondria In Sperm Heads Egg Mitochondrial Genes Are Inherited a Paternally b Maternally The Circular Mitochondrial Genome is Inherited Maternally Disease Genes Present on the Mitochondrial Genome Many Affect Muscles Because Mitochondria Produce Energy Needed For Muscle Activity How Are Mitochondrial Gene Defects Inherited No Mitochondria In Sperm Heads Egg Note



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