VCU MEDC 527 - MEDC 527 quiz 1 (3 pages)

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MEDC 527 quiz 1



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MEDC 527 quiz 1

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Pages:
3
School:
Virginia Commonwealth University
Course:
Medc 527 - Basic Phrm Princ for Pharmacst
Basic Phrm Princ for Pharmacst Documents
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BASIC PHARMACEUTICAL SCIENCE FOR THE PRACTICING PHARMACIST MEDC 527 Fall 2008 Quiz 1 Dr Desai 100 points September 9 2008 STUDENT NAME in CAPITAL Letters ONLY Signature 1 VCU ID IV C Si Ge 2 3 4 5 V N P As Rank the molecules according to their expected mp bp Use 1 for least and 3 for highest mp bp OH OH VI O S Se VII F Cl Br I 6 pts OH HO HO OH 2 Circle the molecule in the pair that is expected to have higher boiling melting point OH OH a CH3CH2F HF b 8 pts COOH COOH 3 Write the Henderson Hasselbach equation for the following equilibrium Define the terms involved PhCOOH H2O 12 pts PhCOO H3O 4 In few sentences explain why I is expected to have lower pKa than II H3C H3C N CH3 Cl I COOH H3C H3C 6 pts COOH CH3 II 1 5 Rank the molecules ions in each series according to their pKa values Use 1 for the least pKa value 2 for the next 18 pts higher and so on a O2N CH2 CH2 COOH CH3 CH COOH CH3 CH COOH COOH NO2 I F COOH COOH b c 6 F CH2 COOH COOH CH3 COOH Br CH2 COOH The molecule underneath is potential diagnostic marker for an anti estrogenic agent Indicate the Kier Hall electronegativity values of the following atoms 8 pts Kier Hall eN Value OH O of phenolic OH I HO 7 CH2 9SO CH2 3CF2CF3 I S F of CF2 In few sentences explain why the bp of I is expected to be higher than that of II 6 pts COOH I II 8 Amyl nitrite is a nitrovasodilator The structure of amyl nitrite is CH3 2CHCH2CH2 O N O Write the electronic structure of its nitrogen and the double bonded oxygen atoms and indicate their hybridization states 8 pts The electronic structure of N is The hybridization state of N is The electronic structure of O is The hybridization state of O is 2 9 Indicate whether the following drugs or biological molecules will exhibit good water solubility at pH 7 2 7 4 Circle the correct answer 16 pts A Soluble OR Insoluble B Soluble OR Insoluble H3C CH3 CH3 O COOH CH3 Gemfibrozil HO Cholesterol C Soluble OR Insoluble D Soluble OR Insoluble CH3 COOH OCOCH3 COOH CH3 H 3C Aspirin 10 Ibuprofen Azidothymidine below is an inhibitor of HIV reverse transcriptase enzyme Write the hybridization state of nonhydrogen atoms marked a oxygen b nitrogen c carbon d nitrogen e oxygen and f nitrogen Also indicate the type of geometry corresponding to the hybridization 12 pts O a b c CH3 HN H2 C e HO Nf N O O Nd Hybridization state Type of Geometry a b c d e f N 3


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