BIOC/CHEM/MMG 205, Biochemistry IUniversity of VermontFall Semester, 2004Instructors Office Phone E-mailMargaret Daugherty* Given B418 656-0344 Margaret.Daugherty @uvm.eduMartin Case Cook A321 656-8264 [email protected]*temporary office and phoneMeeting Time:Mon/Wed/Fri 10:10-11:00, Rowell, room 110Required Text:Biochemistry 3rd Edition, 2005, Garrett & GrishamOrganization:Problem Sets, 6 x 6% (3 for Daugherty, 3 for Case) 36%Exams, 4 x 16% 64%100%Problems sets will be assigned throughout the course. Exams will last 120 minutes -from 7pm to 9 pm in Rowell 103. If you have any scheduling conflicts with the latetime slot, please notify the appropriate professor prior to the exam to reschedule.Exams are closed-book, closed-note exams; no class materials may be used and nooutside help may be used. Due to potential scheduling conflicts, you are not allowedto discuss the exams with anyone else until the answer key is posted.Website: All lecture notes, homeworks and answer keys, and otherinteresting "items" will be posted as pdf files on a website athttp://biochem.uvm.edu/undergradcourses.phplogin: biochemistry password: greatfunGood stuff to know for Part I: Protein Structure &FunctionDr. Daugherty Phone: 656-0344 (temporary)Office: Given B418 (temporary)Email: [email protected] hours (in a review session style): Tuesday 5:30 - 7:30 in Given C443Office hours can also be scheduled by appointmentI encourage students to contact me by email with the smaller "clarification" types ofquestions. I usually respond to emails by the end of the day.Exam I: Monday 9/27/04 from 7:00 - 9:00 pm (Lectures 1 - 11)Exam II: Monday 10/18/04 from 7:00 - 9:00 pm (Lectures 13 - 20)Exams will be held in the Rowell 103 from 7-9 pm!For exams, headphones, Palm Pilots and similar data devices, cell phonesand outside material and help are all prohibited. Calculators arepermitted. I expect students to follow the UVM Honor Code (described indetail at the website http://www.uvm.edu/~dosa/handbook/?Page=Academic.html)Absence from an exam requires prior approval from Dr. Daugherty. Homework is ABSOLUTELY due by the end of class on the due date. Late homeworkwill be severely penalized !. Homework will be returned at the end of the followingclass period, along with an answer key.*Review questions (answers in back of book) are for your benefit only - they reflectthe type of questions & information that may be asked on the exam!Teaching assistant: Pete BresciaOffice hours: Tuesday 3:30 - 4:30; Thursday 10:30 - 11:30Office location: Given Building Room C447 (or C414; same room, different door)Email: [email protected] 205: BIOCHEMISTRY I SYLLABUSDr. Margaret (Peggy) [email protected]: Given Building Room B418 (temporary)Phone: 656-0344Office hours by appointmentLecture Date Topic Reading &Review Questions*GradedHomework1M8/30Introduction & Review ofFundamentalsCH 1: p 2 - 29Review questions:1, 6,7,8,10,112W9/1Review: Water, pH and pKa CH 2: p 31 - 49Review questions:1a,d;2a,e,3,6Homework 1out3F9/3Review of Thermodynamics CH 3: p 51 - 75Review questions:1,2,5,10,11M9/6LABOR DAY --- NO CLASS4W9/8Amino Acids: The Primary Levelof Protein Structure; AminoAcids as Polyprotic AcidsCH 4: p 76-94Review questions:2,3,4,75F9/10Protein Architecture I: Peptidesand the Peptide BondCH 5: p 103 - 108CH6: p 155 - 157Review questions:6M9/13Protein Architecture II:Secondary StructureCH 6: p 155 - 165;p 186-188Review questions:CH6: 1, 4Homework 1due;Homework 2out7W9/15Protein Architecture III: Tertiary,Quaternary StructureCH 5: p 108 - 112CH 6: p 166 - 185; p 194 - 2008F9/17Protein Architecture IV: Tertiary,Quaternary StructureReview questions:CH6: 89M9/20Protein Architecture V:Evolution, Function, Classificationof ProteinsCH 5: p 115 - 117;p 131 - 144Review questionsCH 6: 1010 W9/22Protein & Peptide Chemistry CH 4: p 97 - 100CH 5: 112 - 129Review questions:CH 6: 7Homework 2due:Homework 3out11 F9/24Protein Folding and Stability CH 6: p 153 - 155;176 - 177; 184-19312 M9/27EXAM 1 ☺☺☺☺: 7-9 pmRowell 103 Lectures 1 - 1 1Note time androom change!13 W9/29Enzymes & Kinetics I:Introduction to Enzymes andKineticsCH 13: 404-412Review questions14 F10/1Enzymes & Kinetics II: Michaelis-Menton KineticsCH 13: 412-421Review questions1,2,315 M10/4Enzymes & Kinetics III: MichaelisMenton Kinetis & InhibitionCH 13: 421-438Review questions 416 W10/6Enzymes & Kinetics IV: MichaelisMenton Kinetics & Inhibition;startRegulation.CH 13: 421-438CH 15: 475 - 482Review questions 417 F10/8FALL RECESS - NO CLASS!18 M10/11Enzymes & Kinetics V:MechanismsDr. Stephen Everse teachesClass starts at 10:15CH 14: 442-457Review questions:CH 14: 2. 9-1519 W10/13Enzymes & Kinetics VI:Regulation and AllosteryCH 15: 475-491Review questionsCH 15: 1, 2, 13, 17Homework 3due;Homework 4out with key.20 F10/15Proteins of the Blood I:Hemoglobin & Myoglobin -Comparison of FunctionCH 15: 491 - 503Review questions:CH 15: 8, 1521 M10/18EXAM 2 ☺☺☺☺: 7-9 pmRowell 103 Lectures 13 -20Note time androom