UA PHCL 501A - Sedative-Hypnotic Drugs and Anxiety Disorders (24 pages)

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Sedative-Hypnotic Drugs and Anxiety Disorders



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Sedative-Hypnotic Drugs and Anxiety Disorders

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Pages:
24
School:
University of Arizona
Course:
Phcl 501a - Pharmacological Basis of Therapeutics

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Sedative Hypnotic Drugs and Anxiety Disorders Patrick T Ronaldson PhD Department of Medical Pharmacology University of Arizona Anxiety Term used to describe both symptoms and disorders Occurs normally as signal of impending danger or threat Very common occurs in many disorders in addition to the anxiety disorders Differentiated from fear on basis of whether there is a clear source of danger i e fight or flight response Adaptive value helps to plan and prepare for threat moderate levels enhance learning and performance Maladaptive when chronic severe Anxiety Symptoms include physiological symptoms of activated sympathetic nervous system increased heart rate increased respiration sweating etc cognitive component awareness of being frightened behavioral components urge to escape Anxiety Disorders DSM IV Panic disorder with or without agoraphobia Agoraphobia without panic disorder Specific phobias Social phobia Obsessive compulsive disorder Posttraumatic stress disorder Acute stress disorder Generalized anxiety disorder Anxiety disorder due to a general medical condition Substance induced anxiety disorder Anxiety disorder not otherwise specified Anxiety Disorders Prevalence 17 13 Lifetime Prevalence of Anxiety Disorders 25 7 8 5 3 5 2 5 n sio s e pr De r c rd e ati r o l s m a i i u d de c ttra disor So xiety s Po ss an e str d r ize orde l a r s ne di Ge iety x an nic Pa r rde o dis er isord e d siv es lsive s b u O mp co Kessler RC et al Arch Gen Psychiatry 1994 51 8 19 Stein MB et al JAMA 1998 280 708 713 Kessler RC et al Arch Gen Psychiatry 1995 52 1048 1060 Spectrum of Depression and Anxiety Disorders Posttraumatic stress disorder Social anxiety disorder Depression Panic disorder Obsessive compulsive disorder Generalized anxiety disorder Neurobiology of Anxiety Disorders CNS equilibrium is determined by a balance between excitatory and inhibitory neurotransmission Excitation Glutamate is prototypical NT Inhibition GABA is prototypical NT Inhibition via GABA is



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