8/26/13 1 BIOL 213-501 Molecular Cell Biology Section 501 Tues & Thurs 11:10am – 12:25pm ILSB 1105 Dr.$Steve$W.$Lockless$(8/26$–$10/14)$!Office:[email protected]!!Office$Hours:!!Mon!&!Thurs!4A5pm!!please!put:!“Biol213!–!(your!name)!–!(subject)”!!in!email!subject!line!8/26/13 2 Dr.$Richard$Gomer$(10/15$–$12/11)$!Office:[email protected]!!Office$Hours:!!Mon!&!Thurs!4A5pm!!please!put:!“Biol213!–!(your!name)!–!(subject)”!!in!email!subject!line!Help$sessions$$Heldenfels!117!Tues,!Wed!&!Thurs!6:00A7:00pm!(9/3!–!12/5)!Teaching$Assistant:$Nehemiah!Cox!!(Nehemiah!is!the!TA!for!the!Tuesday!Help!Sessions,!while!other!TAs!will!be!available!Wednesdays!&!Thursdays)!8/26/13 3 Course$Website!!hZp://elearning.tamu.edu/ A !Follow!link!to!VISTA!login!at!TAMU!A !BIOL!213!site!A !Syllabus,!lecture!notes,!grades!!Prerequisites!!BIOL!111/112!and!CHEM!227!!(or!current!enrollment!in!CHEM!227).!8/26/13 4 Exams$and$grading$policies$Three!exams!during!the!semester!and!a!comprehensive!final!A!see!syllabus!for!dates.!!Exams!will!include!short!answer!essays.!!No!curve!A!you!know!where!you!stand!at!all!`mes.!!Challenges!to!test!ques`ons!must!be!in!wri`ng!with!an!explana`on!of!why!you!believe!your!answer!is!correct.!!It!should!be!wriZen!or!typed!on!a!piece!of!paper!and!stapled!to!the!exam,!and!then!turned!in!to!the!instructor.!MakeSup$exams$will$be$given$only$for$UniversitySapproved$absences$and$will$be$given$at$8am$the$Friday$following$the$missed$exam.!!The!hourly!exams!will!count!for!100!points,!and!the!final!exam!will!count!for!150!points,!for!a!maximum!of!450!points.!!!!Grades!will!be!assigned!on!the!following!scale:!!!A!=!405!to!450!points!(≥90%)!B!=!360!to!404!points!(≥80%)!C!=!315!to!359!points!(≥70%)!D!=!270!to!314!points!(≥60%)!F!=!269!or!fewer!points!(<60%)!!Grading$8/26/13 5 Tips$for$how$to$do$well$in$class$1) Eat!breakfast.!2) Read!the!chapter!one!to!two!days!before!the!lecture,!trying!to!explain!the!material!to!yourself.!3) Close!the!book!and!without!referring!to!notes,!“teach”!the!material!to!yourself,!a!friend!or!an!imaginary!audience.!4) Make!notes!on!things!that!you!don’t!understand!and!listen!to!us!explain!it!in!class.!5) Listen!in!class.!6) If!you!s`ll!don’t!understand!a!concept,!ask!a!ques`on!in!class!!7) Aner!the!lecture,!“teach”!the!material!to!yourself!again!to!solidify!what!you!learned!in!the!book!and!lecture.!8) Do!the!problems!in!the!book!before!looking!at!the!answers.!9) Many!of!the!exam!ques`ons!will!cover!material!contained!in!“Be!Able!To”!items!at!the!end!of!lectures.!Active learning We!can!guide!you!in!your!learning,!but!you!will!need!to!do!the!studying!to!learn!the!material.!!Scien`fic!studies!of!different!teaching!techniques!has!shown!that!thinkApairAshare!exercises!increases!student!learning!and!reten`on!of!material;!we!will!occasional!do!these!exercises!in!class!to!help!you!grasp!key!concepts.!We!do!this!to!increase!your!learning,!not!to!decrease!the!amount!that!we!lecture.!!!8/26/13 6 Exam$1$$is$on$$Tuesday,$Sept$17th$What$will$you$learn$by$studying$Cell$and$Molecular$Biology?$• Cells!are!the!fundamental!unit!of!life!• All!cells!have!similar!chemistry!• Mechanis`c!understanding!of!cellular!func`on!and!dysfunc`on!8/26/13 7 Be Able To • Explain the three central tenets of The Cell Theory. • Describe and sketch Pasteur’s experiment of 1864. • Predict the outcome of Pasteur’s experiment if all cells did not come from other cells. • Describe the difference between pasteurization and sterilization. Anton$van$Leeuwenhoek$$Robert$Hooke$Algae!Spirogyra!(1674))Cork!(1665))The$Cell$Theory!8/26/13 8 The$Cell$Theory!In$1838,$$Schleiden$&$Schwann$proposed$two$tene ts$ of$the$cell$theory:$$1. !All!organisms!are!composed!of!one!or!more!cells.!2. !The!cell!is!the!structural!unit!of!life.!1855,$Virchow$proposed$a$third$tenet$of$the$cell$theory:$$3.! !Cells!can!only!arise!by!division!from!a!preexis`ng!cell.!!Pasteur$Experiment$(1864)$Boil!Incubate!Strong!support!for!germ!theory!and!against!spontaneous!genera`on!–!Omne)vivum)ex)ovo)(All!life!is!from!eggs)!!!8/26/13 9 DNA$Replicabon$DNA$(blueprint)!Energy$Membrane$Transport$Cytoskeleton$Replicate$&$Repair$Proteins$(executors)!mRNA$Transcrip`on!Transla`on!Communicabon$8/26/13 10 Three$Domains$of$Life$8/26/13 11 DNA$(blueprint)!Energy$Membrane$Transport$Cytoskeleton$Replicate$&$Repair$Proteins$(executors)!mRNA$Transcrip`on!Transla`on!Communicabon$What$will$you$learn$by$studying$Cell$and$Molecular$Biology?$• Cells!are!the!fundamental!unit!of!life!• All!cells!have!similar!chemistry!• Mechanis`c!understanding!of!cellular!func`on!and!dysfunc`on!How do we know all of this?The Capstone Research Program in Biology, provides undergraduates with the opportunity to perform original and independent research. All courses are offered this Fall. The Capstone Program encompasses 4 semesters: - BIOL 295: Research Fundamentals. Principles of research: formulating hypotheses, designing experiments, making observations, and drawing conclusions. One Credit. - BIOL 395: Directed Investigation in Bioinformatics.* Using the tools of bioinformatics to conduct independent research that creates new knowledge. Students will pursue unique projects, collecting and interpreting data on newly-sequenced genomes to be shared with the scientific community. Two Credits. - BIOL 494: Independent Bioinformatics Research.* Testing hypotheses, generating new data, and interpreting findings through intensive independent research on unexplored genomes. Two Credits. - BIOL 495: Research Communication (W course). Communicating the methods, results and conclusions of research. Provides students with the skills to effectively communicate, in oral and written form, with a professional audience. This course is open this Fall to all who have at least one semester of independent research experience Two Credits. *Students may also conduct their own research independently with the support of a faculty advisor, substituting two semesters of BIOL 491: Research for BIOL 395 and 494. To begin Semester 1 this Fall, register for: BIOL 295 Section 501: Research Fundamentals, meeting Wednesday 1:50-2:40 with Prof. Keith Maggert. Questions? Contact [email protected] or visit