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J P Costanzo and R E Lee Jr Am J Physiol Regulatory Integrative Comp Physiol 261 1346 1350 1991 You might find this additional information useful This article has been cited by 1 other HighWire hosted article Osmotic and freezing tolerance in spermatozoa of freeze tolerant and intolerant frogs J P Costanzo J A Mugnano H M Wehrheim and R E Lee Jr Am J Physiol Regulatory Integrative Comp Physiol September 1 1998 275 3 R713 R719 Abstract Full Text PDF Additional material and information about American Journal of Physiology Regulatory Integrative and Comparative Physiology can be found at http www the aps org publications ajpregu This information is current as of January 9 2008 The American Journal of Physiology Regulatory Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization ranging from molecules to humans including clinical investigations It is published 12 times a year monthly by the American Physiological Society 9650 Rockville Pike Bethesda MD 20814 3991 Copyright 2005 by the American Physiological Society ISSN 0363 6119 ESSN 1522 1490 Visit our website at http www the aps org Downloaded from ajpregu physiology org on January 9 2008 Medline items on this article s topics can be found at http highwire stanford edu lists artbytopic dtl on the following topics Physiology Erythrocytes Physiology Anura Medicine Osmotic Fragility Chemistry Osmosis Physiology Humans Freeze thaw injury in erythrocytes wood frog Rana sylvatica JON P COSTANZO AND RICHARD Department of Zoology Miami University of the freeze tolerant E LEE JR Oxford Ohio 45056 cryoprotectants rapidly mobilized from the liver in direct response to ice formation To date no studies of freeze tolerant vertebrates have examined the responses of blood constituents to freezing and thawing This is surprising because the heritage of cryobiology is founded in research



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