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Chitosan: an integrative biomaterial for lab-on-a-chip devices



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CRITICAL REVIEW www rsc org loc Lab on a Chip Chitosan an integrative biomaterial for lab on a chip devices S T Koev a P H Dykstra a X Luo b G W Rubloff c W E Bentley b G F Payneb and R Ghodssi a Received 24th May 2010 Accepted 17th August 2010 DOI 10 1039 c0lc00047g Chitosan is a naturally derived polymer with applications in a variety of industrial and biomedical fields Recently it has emerged as a promising material for biological functionalization of microelectromechanical systems bioMEMS Due to its unique chemical properties and film forming ability chitosan serves as a matrix for the assembly of biomolecules cells nanoparticles and other substances The addition of these components to bioMEMS devices enables them to perform functions such as specific biorecognition enzymatic catalysis and controlled drug release The chitosan film can be integrated in the device by several methods compatible with standard microfabrication technology including solution casting spin casting electrodeposition and nanoimprinting This article surveys the usage of chitosan in bioMEMS to date We discuss the common methods for fabrication modification and characterization of chitosan films and we review a number of demonstrated chitosan based microdevices We also highlight the advantages of chitosan over some other functionalization materials for micro scale devices 1 Introduction a Department of Electrical and Computer Engineering Institute for Systems Research ISR University of Maryland College Park MD 20742 USA E mail ghodssi umd edu b Fischell Department of Bioengineering Center for Biosystems Research University of Maryland College Park MD 20742 USA c Department of Materials Science and Engineering Institute for Systems Research ISR University of Maryland College Park MD 20742 USA These authors contributed equally to this work Currently address Center for Nanoscale Science and Technology NIST Gaithersburg MD 20899 USA such as DNA enzymes or antibodies to operate with sufficient



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