PowerPoint PresentationSlide 2Slide 3Slide 4Slide 5Slide 6Slide 7Slide 8Slide 9Slide 10Slide 11Slide 12Slide 13Slide 14Two States of the ArrayB. Ding & N.C. Seeman, Science 314, 1583-1585 (2006).Transitions in the ArrayB. Ding & N.C. Seeman, Science 314, 1583-1585 (2006)..Transitions in the Array (Zoom)B. Ding & N.C. Seeman, Science 314, 1583-1585 (2006).Programming an Array for AssemblyA. Carbone & N.C. Seeman, Proc. Nat. Acad. Sci. (USA) 99 12577-12582 (2002).A Ribosome-Like Device:A DNA Nanomechanical Translation Machine Shiping LiaoA Drawing of the DeviceLiao, S. & Seeman, N.C. (2004), Science 306, 2072-2074.Movable Sticky EndsMovable Sticky EndsFixed Sticky EndsPrinciples of OperationI1 2 743 5PX1 JX226IIIIIVIV1 2 73 654PX1 JX22I IIIIIIVV13DX312DX24 6DX447DX557DX75 6DX6DX2 DX5Liao, S. & Seeman, N.C. (2004), Science 306, 2072-2074.Possible ProductsLiao, S. & Seeman, N.C. (2004), Science 306, 2072-2074.Relationship toTraditional Components2 4 60 1I IIIIIIVVA B3 75PX1 PX2Message Codon EquivalentMessage Codon EquivalentAmino Acid EquivalenttRNA EquivalentLiao, S. & Seeman, N.C. (2004), Science 306, 2072-2074.DX Molecules Correspond to Aminoacyl tRNA Molecules Anticodon EquivalentSequenceNNN------------------------------------NNN1. MS beads2. Release (Cleave DS2)3. Ligate4. DenatureIVIIIVI IIA B0 1 2 743 65PX1 JX22I VVI I IPX1 JX22A B0 1 2 743 65I IIFailedAssembliesB1. MS beads2. Release (Cleave DS1)3. Add DS2Purification, Ligation & AnalysisLiao, S. & Seeman, N.C. (2004), Science 306, 2072-2074.Sequencing Result*All Combinations WorkLiao, S. & Seeman, N.C. (2004), Science 306, 2072-2074.Polymer UnitVisualized ApplicationDX MoleculeOrganized PolymersDNA Walking BipedBill ShermanSchematic of the Device and SidewalkSherman, W.B. & Seeman, N.C. (2004), NanoLett. 4,