10.37: CHEMICAL & BIOLOGICAL REACTION ENGINEERING SPRING 2009 Instructors Professor William Green Room 66-270A Telephone: 3-4580 [email protected] Office Hours: by appointment Professor Gregory Stephanopoulos Room 56-469C Telephone: 3-4583 [email protected] Office Hours: by appointment Teaching Assistants: Office Hours: Monday 5:30-8:30 (TBA), Tuesday 5:30-8:30 (TBA) Anita Shukla NE47-487 x4-6429 [email protected] Jamila Saifee 66-244 x3-6542 [email protected] Nick Parsons 66-253 x2-2450 [email protected] Class Meetings Lectures Room 66-110 WF 11:00-12:00 Recitation-1 Room 56-154 M 11:00-12:00 Recitation-2 Room 56-154 M 12:00-1:00 Required Text: Elements of Chemical Reaction Engineering, H. S. Fogler, Prentice-Hall, 4th edition, Web Site: http://stellar.mit.edu/S/course/10/sp09/10.37/index.html Reserve Book Room: 14N-132 (for reference) Fogler, F. S., Elements of Chemical Reaction Engineering, 4th edition, 2005 Koretsky, M.D., Engineering and Chemical Thermodynamics, 9.1-9.5, 9.7 Levenspiel, O., Chemical Reaction Engineering Smith, J. Chemical Engineering Kinetics Steinfeld, et al., Chemical Kinetics and Dynamics Bailey, J.E. and Ollis D.F. Biochemical Engineering Fundamentals Stephanopoulos, Aristidou and Nielsen, Metabolic Engineering Course Work and Grades: Homework (25% of grade): Weekly problem sets will be assigned approximately 6-7 days in advance of their due date. They will be graded and returned the following week. Homework Policy and Honor Code: While students are encouraged to discuss problem solutions and strategies, they are expected to work individually in arriving at solutions. Electronically copying or cutting & pasting any section of another student’s homework will be considered cheating and will lead to disciplinary action against both the copier and any student who made the electronic version available before the due date. Please do each problem on separate & stapled sheets with your name on it. HOMEWORK IS NORMALLY DUE AT THE END OF CLASS ON WEDNESDAYS. Late homework will be accepted until 10 pm of the date it is due at the TA’s office. 50% of the grade will be deducted from late homework unless there are extenuating circumstances that justify the late submission. Solutions to problem sets will be posted on the web at 10 pm on the due date. Examinations (20%, 20%, 35% of grade): The first two exams will be 1 hour long and will be given during class time. The third exam will be given during the final exam period and will be three hours long. Recitation Sections: The purpose of the recitation section is to give you practice working difficult problems in a supportive environment, with a focus on moving from the problem statement to solvable systems of equations. We will also review homework solutions, discuss problem solving strategies, answer questions concerning10.37 Chemical & Biological Reaction Engineering Spring 2005 3/17/09 22lecture material, discuss exam solutions. You must have read and thought about the homework problems before you come to recitation. Be prepared to be asked to do problems on the chalkboard. 10.37 Course Schedule (Spring 2009) February 4 (W) L1. Anatomy of a chemical reaction: Reaction stoichiometry, lumped stoichiometries in complex systems such as bioconversions and cell growth (yields); extent of reaction, independence of reactions, measures of concentration. Single reactions and reaction networks, bioreaction pathways (GS). (Reading Assignment (RA): Notes) 6 (F) L2. The reaction rate: Definition in terms of reacting compounds and reaction extent; rate laws, Arrhenius equation, elementary, reversible, non-elementary, catalytic reactions. Rate of cell growth and cell-dependent reactions (GS). (RA: Notes, Sections: 1.1, 3.1, 3.2, 3.3) 9 (M) Recitation 1 (GS) 11 (W) L3. Reaction mechanisms and rate laws: Reactive intermediates and steady state approximation in reaction mechanisms. Rate-limiting step. Chain reactions, pyrolysis reactions (GS). (RA: Notes, Sections 7.1). Problem set 1 due 13 (F) L4. Kinetic treatment of chain reactions. Pyrolysis, polymerization, long chain approximation (GS) (RA: TBA) 16 (M) Presidents Day 17 (T) Recitation 2 (WHG) 18 (W) L5. Reaction equilibrium 1 (WHG) Problem set 2 due. 20 (F) L6. Reaction equilibrium 2 (WHG) 23 (M) Recitation 3 (WHG) 25 (W) L7. Kinetics of enzymatic reactions. Michaelis-Menten kinetics; enzymatic regulation, enzyme denaturation and deactivation; effect of temperature, pH and other factors on enzyme kinetics; industrial and medical applications of enzymes (GS). (RA: Notes, Section 7.2, 7.3). Problem set 3 due 27 (F) L8. Kinetics of cell-associated processes. Cell growth kinetics; substrate uptake and product formation in microbial growth, specific rates; mammalian cell growth and intracellular kinetic processes (GS). (RA: Section 7.4) March 2 (M) Recitation 4 (WHG) 4 (W) L9. The reactor environment. The batch reactor; isothermal design equations; reactor sizing for constant volume and variable volume processes; (WHG) (RA: Sections 1.2, 1.3, 1.5, 2.1, 2.2, 3.5, 3.6.3, 4.1, 4.2.1) Problem set 4 due 6 (F) L10. The reactor environment. The Plug Flow Reactor (GS). (RA: 1.4.2, 1.4.3, 2.1, 2.3, 2.4(PFR), 2.5(PFR), 3.6, 4.4, 4.5)10.37 Chemical & Biological Reaction Engineering Spring 2005 3/17/09 33 9 (M) Recitation 5 (GS) 11 (W) L11. The reactor environment. Continuous Stirred Tank Reactor . reactions in a perfectly mixed tank at steady state reactor. (GS). (RA: 1.4.1, 2.3, 2.4, 2.5, 2.6, 3.6, 4.3, 4.6). Problem set 5 due 13 (F) L12. Reactor size comparisons for PFR and CSTR. Reactors in series and in parallel. Unsteady state operation: start up of CSTR’s and semi-continuous or fed batch fermentors (GS). (RA: Sections 2.2, 2.3, 2.4, 2.6, 4.10) 16 (M) Recitation 6 (WHG) 18 (W) L13. Analysis of rate equations. Parallel, series (consecutive) reactions, systems of reactions and bioreaction networks. Definitions of yield and selectivity; impact of reactor choice on yield and selectivity of products (WHG). (RA: Chapter 6) Problem set 6 due 20 (F) Exam 1, in class 23-27 Spring Vacation 30 (M) Recitation 7 (GS) April 1 (W) L14. Biological reactors. The batch reactor, theory of the chemostat, fed batch or semi-continuous fermentor operation; other bioreactor configurations (GS). (RA: Notes) 3 (F) L15. Data