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Slide 1Winter 2011 Biol/Chem 472 MetabolismSlide 3www.whfreeman.com/lehninger5eStudent Media Resources www.whfreeman.com/lehninger5eAdditional Saleable Supplement: The Absolute Study Guide & Solutions ManualSlide 7What is Biochemistry?Lehninger: “Molecular Logic”Slide 10Table 1-3 Elemental Composition of the Human Body.Map of the major metabolic pathways in a typical cell.Biol/Chem 472 Expected OutcomesSlide 14Slide 15Slide 16Slide 17Slide 18Slide 19Figure 11-1 The stereochemical relationships, shown in Fischer projection, among the D-aldoses with three to six carbon atoms.Slide 21Slide 22Figure 11-2 The stereochemical relationships among the D-ketoses with three to six carbon atoms.Slide 24Figure 11-3 The reactions of alcohols with (a) aldehydes to form hemiacetals and (b) ketones to form hemiketals.Slide 26Figure 11-4 Cyclization reactions for hexoses.Figure 11-5 The anomeric monosaccharides a-D-glucopyranose and b-D-glucopyranose, drawn as both Haworth projections and ball-and-stick models.Slide 29Figure 11-8 The acid-catalyzed condensation of a-D-glucose with methanol to form an anomeric pair of methyl-D-glucosides.Slide 31Figure 11-11 N-Acetylneuraminic acid in its linear and pyranose forms.Slide 33Slide 34Slide 35Slide 36Slide 37Slide 38Figure 11-13 Electron micrograph of the cellulose fibers in the cell wall of the alga Chaetomorpha melagonium.Figure 11-14 The primary structure of cellulose.Figure 11-15 Proposed structural model of cellulose.Slide 42Slide 43Slide 44Cross-bridging and esterification in pectinsSlide 46Figure 11-16 Structure of chitin.Figure 11-17a a-Amylose. The D-glucose residues of a-amylose are linked by a(1 ® 4) bonds (red).Figure 11-17b a-Amylose. This regularly repeating polymer forms a left-handed helix.Figure 11-18a Amylopectin. Its primary structure near one of its a(1 ® 6) branch points (red).Figure 11-18b Amylopectin. (b) Its bushlike structure with glucose residues at branch points indicated in red.Figure 11-20 The disaccharide repeating units of the common glycosaminoglycans.Figure 11-23 Schematic diagram comparing the cell envelopes of (a) gram-positive bacteria and (b) gram-negative bacteria.Figure 11-24a Chemical structure of peptidoglycan. (a) The repeating unit of peptidoglycan.Figure 11-24b Chemical structure of peptidoglycan. (b) The S. aureus bacterial cell wall peptidoglycan.Figure 11-25 Structure of penicillin.Figure 11-26 Enzymatic inactivation of penicillin.Figure 11-29a N-Linked oligosaccharides. (a) All N-glycosidic protein attachments occur through a -N-acetylglucosamino–Asn bond to Asn–X–Ser/Thr.Figure 11-29c N-Linked oligosaccharides. (c) Some examples of N-linked oligosaccharides.Figure 11-30 Some common O-glycosidic attachments of oligosaccharides to glycoproteins (red).Figure 11-33a The surfaces of (a) a normal mouse cell as seen in the electron microscope. (b) a cancerous cell as seen in the electron microscope.Living cells are not at equilibrium!Slide 63Slide 64Slide 65Slide 66Slide 67Slide 68Slide 69Slide 70Slide 71Slide 72Slide 73Slide 74Slide 75Slide 76Slide 77Slide 78Slide 79Slide 80Slide 81Slide 82Winter 2011 Biol/Chem 472 Metabolism•Instructor: Gerry Prody•Office CB444•Office hrs: TBA•[email protected]•http://lightning.chem.wwu.edu/dept/facstaff/prody/prody-472.htmThe required textbook for this course is: LEHNINGER Principles of Biochemistry 5/e by David L. Nelson and Michael M. Cox(©2008, W.H. Freeman & Company)Welcome to Biochemistrywww.whfreeman.com/lehninger5e This site is chock full of resources to help you succeed in the course.Free Companion WebsiteStudent Media Resourceswww.whfreeman.com/lehninger5e •Interactive quizzes help you practice for exams•Animated Enzyme Mechanisms and Animated Biochemical Techniques help you understand key mechanisms and techniques at your own pace•Molecular Structure Tutorials allow you to explore in more depth the molecular structures included in the text•Living Graphs illustrate key equations from the book allowing you to do what if scenarios by changing the parameters•Lecture Companion Art allow you to print figures and tables for note-taking and reviewAdditional Saleable Supplement:The Absolute Study Guide & Solutions ManualIt combines an innovative study guide with a reliable solutions manual providing extended solutions to the end-of-chapter problems in the textbook. It includes for each chapter:-Major Concepts: A roadmap through the chapter-What to Review: Questions that recap key points from previous chapters-Discussion Questions: Designed for individual review, study groups, or classroom discussion-A Self-Test: “Do you know the terms?”; crossword puzzles; multiple-choice, fact-driven questions; and questions that ask students to apply their knowledgeTo learn more contact your local bookstore.Need support? 1-800-936-6899 Monday-Friday, 9-5 [email protected] is Biochemistry?•the systematic torture of students with copious incomprehensible jargon, cryptic fomulae, and impossible insoluble problems.“Biochemistry is the study of Life as a process that can be understood.”Primary Objective: understand the molecular mechanisms that constitute the living state (“Molecular Logic”)Lehninger: “Molecular Logic”“A living cell is a self-assembling, self-regulating, self-replicating isothermal open system of organic molecules operating on a principle of maximum economy of parts and processes; it promotes many consecutive, linked organic reactions for the transfer of energy and for the synthesis of its own components by means of organic catalysts that it produces itself.”Biol/Chem 471; Biol/Chem 472 ; Biol/Chem 473Elemental composition of the earth’s surface, including crust, oceans and atmosphere.Element Percent by massOxygen 49.1Silicon 26.1Aluminum 7.5Iron 4.7Calcium 3.4Sodium 2.6Potassium 2.4Magnesium 1.9Hydrogen 0.88Titanium 0.58Chlorine 0.19Carbon 0.09All others 0.56Table 1-3 Elemental Composition of the Human Body.Page 29Map of the major metabolic pathways in a typical cell.Biol/Chem 472 Expected Outcomes•draw enzymatic reactions correctly •correctly calculate Gº’ and G for a given step or a series of steps in a pathway•rationalize and/or predict features of pathway regulation and describe regulatory mechanisms•recognize how concentrations of metabolites are regulated and the impact that changes in flux and/or concentration will have on other processes.Note that figures labeled as Ch 11


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